Gout

Question 1

What to use for acute gout attacks

Answer 1

NSAIDs, colchicine (first sign of attack), prednisone, anakinra

Question 2

How to treat hyperuricemia

Answer 2

dietary mod, rate lowering meds, attach prophylaxis (want <6)

Question 3

To use allopurinol, check for

Answer 3

hypersensitivity-> HLA-B*5801

check in Thai, Chinese, Korean, black patients

Question 4

secrete drug drug interactions (azathioprine) with allopurinol can lead to

Answer 4

profound cytopenias

Question 5

Pegloticase is:

Answer 5

peg-lated uricase to turn uric acid to allantoic acid

Question 6

purine restriction will only reduce uric acid by ____

Answer 6

1mg/dL

Question 7

Colchicine MOA

Answer 7

neutrophil inhibitor

IL1 inhibitor?

Question 8

Big thing to lower urate acid:

Answer 8

Xanthine oxidase inhibitor:

allopurinol and fuxostat

Question 9

Acute gout: __, __, __

Answer 9

NSAIDs, colchicine, prednisone

Question 10

chronic gout:

Answer 10

allopurinol (or other rate lowering), concurrent prophylaxis

Question 11

Risk of allopurinol can be mitigated by starting at a dose 1.5x ___ and _____

Answer 11

eGFR and increasing slowly

Question 12

If someone does not take a ______ in addition to urate lowering meds, they will have more flares at first

Answer 12

prophylaxis (naproxen or colchine)