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mol R tyr-kinase > R oncogènes > Flashcards

R oncogènes Flashcards

1
Q

HERB2

A

famille de EGFR
transmbr hétérodimérique = prolifération c
activité TK intrinsèque (pas besoin ligand)
PIK3 activé = prolifération, angiogénèse et inhibition apoptosis
trastuzumab

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2
Q

Bcr-Abl

A

protéine oncogène exprimé dans leucémie myéloïde chronique
translocation chromosomique = activité oncogène
activité TK continue
imatinib

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mol R tyr-kinase (5 decks)

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