Quiz2

Question 1

What is OCTREOTIDE?

Answer 1

A somatostatin analog used to reduce GH release and treat hormone-secreting tumors

It is 45 times more potent than somatostatin in inhibiting GH release.

Question 2

What are MENOTROPINS?

Answer 2

Purified extract of FSH and LH, also known as menopausal gonadotropins (hMG)

Used for fertility treatments.

Question 3

What is the main function of FOLLICLE-STIMULATING HORMONE (FSH)?

Answer 3

Direct ovarian follicle development

FSH also stimulates the conversion of androgens to estrogens by granulosa cells.

Question 4

What is LUTROPIN ALFA?

Answer 4

The recombinant form of human LH introduced in the US in 2004

Approved for use with follitropin alfa for follicular development.

Question 5

What are the available forms of purified FSH?

Answer 5

• Urofollitropin (uFSH)
• Follitropin alfa
• Follitropin beta

Question 6

What is the relationship between LH and ovarian steroidogenesis?

Answer 6

Both FSH and LH are necessary for ovarian steroidogenesis

LH stimulates androgen production in the theca cells during the follicular phase.

Question 7

What is the purpose of somatostatin receptor scintigraphy?

Answer 7

To localize neuroendocrine tumors having somatostatin receptors

It uses radiolabeled octreotide.

Question 8

What are common adverse effects of Lutropin?

Answer 8

• Nausea
• Vomiting
• Abdominal cramps
• Flatulence
• Steatorrhea

Question 9

What is CHORIONIC GONADOTROPIN (hCG)?

Answer 9

A hormone produced by the human placenta and excreted into urine

Choriogonadotropin alfa (rhCG) is a recombinant form of hCG.

Question 10

What symptoms are indicative of hypogonadism?

Answer 10

• Delayed puberty
• Retention of prepubertal secondary sex characteristics

Question 11

What is PEGVISOMAT?

Answer 11

A GH receptor antagonist used in the treatment of acromegaly

It is a polyethylene glycol derivative of a mutant GH.

Question 12

What is a notable use of gonadotropins in male fertility?

Answer 12

Induction of ovulation in women with anovulation

This can be due to various causes such as hypogonadotropic hypogonadism or polycystic ovary syndrome.

Question 13

True or False: Lutropin has been approved for use with all preparations of FSH.

Answer 13

False

It has only been approved for use with follitropin alfa.

Question 14

Fill in the blank: Long-term use of octreotide can lead to _______.

Answer 14

Vitamin B12 deficiency

Question 15

What is the primary effect of gallbladder sludge?

Answer 15

A collection of cholesterol, calcium, bilirubin, and other compounds in the gallbladder

This may occur in 20-30% of patients after 6 months of octreotide use.

Question 16

What is the role of LH during the luteal phase of the menstrual cycle?

Answer 16

Controls estrogen and progesterone production

If pregnancy occurs, hCG takes over this control.

Question 17

What is the black-box warning associated with chorionic gonadotropin in the US?

Answer 17

Its use for weight loss

This warning indicates potential risks and lack of efficacy for this purpose.