Quiz - Lec 9-11 and HW Flashcards
OnPattro (patisiran) is an RNAi therapeutic for ppl with hereditary transthyretin-mediated amylodiosis. Which class of drug is this under?
a. RNA interference (antisense)
b. mRNA medicine
c. monoclonal antibodies
d. gene therapy
e. CRISPR-mediated
f. stem cell therapy
a. RNA interference (antisense)
PD1 and PDL-1 drugs fall under which drug class?
a. RNA interference (antisense)
b. mRNA medicine
c. monoclonal antibodies
d. gene therapy
e. CRISPR-mediated
f. stem cell therapy
c. monoclonal antibodies
Luxturna is an example of which type of drug?
a. RNA interference (antisense)
b. mRNA medicine
c. monoclonal antibodies
d. gene therapy
e. CRISPR-mediated
f. stem cell therapy
d. gene therapy
what does Luxturna treat?
rare form of inherited vision loss (it is a gene therapy drug)
what type of drug class is being used for the blood disorder beta-thalassemia?
a. RNA interference (antisense)
b. mRNA medicine
c. monoclonal antibodies
d. gene therapy
e. CRISPR-mediated
f. stem cell therapy
e. CRISPR-mediated
target for CRISPR based gene correction therapy
a. DNA
b. RNA
c. protein
a. DNA
monoclonal antibodies target
a. DNA
b. RNA
c. protein
c. protein
explain the antibody-drug conjugate
ADCs bind to their target antigens and are interalized via endocytosis and eventually leads to apoptotic cell death of the cancer cell
which of the following identifies and destroys virus infected cells?
a. B cells
b. T-helper cells
c. cytotoxic T cells
d. monoclonal antibodies
c. cytotoxic T cells
Zolgensma is a drug that falls under which category?
a. RNA interference (antisense)
b. mRNA medicine
c. monoclonal antibodies
d. gene therapy
e. CRISPR-mediated
f. stem cell therapy
d. gene therapy (AAV)
which of the following stem cell therapies is the most promising?
a. induced pluripotent stem cells (iPSCs)
b. embryonic stem cells (ESC)
c. neural stem cells (NSC)
d. progenitor cells
a. induced pluripotent stem cells (iPSCs)
what is an odds ratio?
measure of an association between an exposure and an outcome
inc risk for a phenotype by carrying a specific genotype/allele compared to the pts w/o carrying
what does an odds ratio = 1 mean?
a. no association
b. inc risk
c. dec risk
a. no association
what does an odds ratio > 1 mean?
a. no association
b. inc risk
c. dec risk
b. inc risk
what does an odds ratio < 1 mean?
a. no association
b. inc risk
c. dec risk
c. dec risk
if the 95% CI is greater than 1, there is a significant __________ effect
a. risk
b. protective
a. risk
if the 95% CI is less than 1, there is a significant __________ effect
a. risk
b. protective
b. protective
why do clinical studies often use the median but not the mean? (2 reasons)
-faster
-data may not be normal distribution
what does ICER stand for?
incremental cost-effectiveness ratio
Repatha has a hazard ratio of ____ relative reduction in CV risk compared to statin
0.85 [.79-0.92]
3 PD-1 blocker drugs
-pembrolizumab (Keytruda)
-nivolumab (Opdivo)
-cemiplimab (Libtayo)
3 PD-L1 blocker drugs
-atezolizumab
-avelumab
-durvalumab
what do oloparib, niraparib, etc target?
BRAC1 mutation (these are PARP inhibitors)
what do binimetinib, trametinib, and cobimetinib target?
KRAS mutation (MEK pathway)
KRAS may activate what two pathways?
-RAF-MEK pathway
-PI3K pathway
which 3 drugs are CDK4 and CDK6 inhibitors?
palbociclib, ribociclib, abemaciclib (the “ciclibs”)
what is the drug combo for melanoma pts with NRAS mutation?
ribociclib (Kisqali) + binimetinib (Mektovi)
