Quiz Ch28

Question 1

1. Which of the following is TRUE regarding fetal and adult hemoglobin?
   A. Fetal hemoglobin is composed of two α- and two γ-chains.
   B. Adult hemoglobin is composed of two α- and one γ-chain.
   C. Adult hemoglobin is HbF and HbA.
   D. Three of the embryonic hemoglobins are Gower 1, 2, and 3.

Answer 1

A. Fetal hemoglobin is composed of two α- and two γ-chains

Question 2

2. Which of the following is TRUE regarding anemia in children?
   A. The most common cause is sickle cell disease.
   B. Anemia is the most common blood disorder in children.
   C. There is only one cause of hemolytic anemia.
   D. Children rarely present with iron deficiency anemia.

Answer 2

B. Anemia is the most common blood disorder in children.

Question 3

3. Which of the following statements is TRUE regarding iron deficiency anemia?
   A. Whites are more commonly affected.
   B. Incidence is most common in those children older than 2 years.
   C. It is common in children due to their extremely high need for iron for normal growth.
   D. There is decreased risk in children of homeless women.

Answer 3

C. It is common in children due to their extremely high need for iron for normal growth.

Question 4

4. Which of the following is TRUE regarding iron deficiency?
   A. Splenomegaly is present in 90% of those affected.
   B. Hemoglobin of less than 5 g/dl may be accompanied by pallor.
   C. Hemoglobin of 10 g/dl is generally accompanied by tachycardia.
   D. Widening of sutures is an early sign of iron deficiency.

Answer 4

B. Hemoglobin of less than 5 g/dl may be accompanied by pallor.

Question 5

5. Which of the following is a TRUE statement regarding maternal antibodies?
   A. Placental detachment does not result in fetal erythrocytes crossing the placenta.
   B. The first Rh-incompatible pregnancy usually presents with severe complications.
   C. Anti-Rh antibodies are formed only in the response to transfusion.
   D. ABO incompatibility can cause hemolytic disease without erythrocytes escaping maternal circulation.

Answer 5

D. ABO incompatibility can cause hemolytic disease without erythrocytes escaping maternal circulation.

Question 6

6. Which of the following is the appropriate term for an alloimmune disease in which maternal blood and fetal blood are antigenically incompatible?
A.   Erythroblastosis fetalis  
B.   Hydrops fetalis  
C.   Icterus neonatorum  
D.   Icterus gravis neonatorum

Answer 6

A. Erythroblastosis fetalis

Question 7

7. Which of the following is TRUE regarding the Coombs test?
   A. Indirect Coombs confirms the diagnosis of antibody-mediated hemolytic disease.
   B. Indirect Coombs measures antibodies to the mother’s circulation.
   C. Direct Coombs indicates if the fetus is at risk for hemolytic disease.
   D. Direct Coombs measures free antibodies.

Answer 7

B. Indirect Coombs measures antibodies to the mother’s circulation.

Question 8

8. Which of the following is TRUE regarding G6PD deficiency?
   A. Most commonly found in females
   B. Most common manifestation is polycythemia
   C. Associated with icterus neonatorum
   D. Associated with green bean ingestion

Answer 8

C. Associated with icterus neonatorum

Question 9

9. Which of the following is associated with hereditary spherocytosis?
   A. Autosomal recessive trait
   B. 25% are new mutations
   C. Results in Heinz bodies
   D. Another name for this disease is kernicterus

Answer 9

B. 25% are new mutations

Question 10

10. Which of the following terms describes a person with Hb(s) and another type of abnormal Hgb?
A.   Sickle cell anemia  
B.   Sickle cell thalassemia  
C.   Sickle cell trait  
D.   Hereditary spherocytosis

Answer 10

B. Sickle cell thalassemia

Question 11

11. Which of the following is a TRUE statement regarding sickle cell disease?
    A. Sickle cell trait is the homozygous form of the disease.
    B. Sickle cell disease means a person has HbA genes.
    C. It is most common in European descent.
    D. It is an autosomal recessive disease.

Answer 11

D. It is an autosomal recessive disease.

Question 12

12. Which of the following is the most common trigger for sickling?
A.   Hypoxemia  
B.   Decreased hydrogen ions  
C.   Decreased plasma osmolality  
D.   High temperature

Answer 12

A. Hypoxemia

Question 13

13. Which of the following is the appropriate term for a transient cessation in red blood cell production resulting in acute anemia?
A.   Vaso-occlusive crisis  
B.   Aplastic crisis  
C.   Sequestration crisis  
D.   Hyperhemolytic crisis

Answer 13

B. Aplastic crisis

Question 14

14. Which of the following hemophilias is autosomal recessive and is found equally in males and females?
A.   Hemophilia A  
B.   Hemophilia B  
C.   Hemophilia C  
D.   von Willebrand disease

Answer 14

C. Hemophilia C