Quiz Flashcards
Lidocaine is effective in the treatment of ventricular tachycardias because it…
blocks the inactivation gate of the sodium channel
Digoxin can be a useful drug in the treatment of supraventricular tachycardias because it…
makes the membrane potential more positive releasing acetylcholine from parasympathetic nerves
Amlodipine and verapamil are both calcium channel blockers, what property makes verapamil the more effective anti-arrhythmic agent ?
Lack of effect on the calcium channel at rest
Which additional property makes propranolol the most useful beta blocker to help control the arrhythmias which occur immediately following a heart attack ?
Sodium channel block
In the treatment of heart failure, which transport protein or ion channel is inhibited by the loop diuretic, furosemide?
Na/K/2Cl transporter
ACE inhibitors reduce the circulating levels of which adrenal hormone ?
Aldosterone
Which drug exerts a direct inotropic effect (+ force of contraction) on heart muscle? Ramipril Furosemide Losartan Digoxin Spironolactone Glyceryl Trinitrate
Digoxin
In chronic heart failure beta blockers are…..
Contra-indicated
Beneficial by slowing the heart rate
Beneficial by depressing the myocardium
Beneficial by increasing oxygen demand
Effective by blocking reflex sympathetic responses which stress the failing heart
Effective by blocking reflex sympathetic responses which stress the failing heart
For which CVS drug is BRONCHOSPASM a potential side effect? Morphine Beta blocker Calcium Antagonist Aspirin Nitrate ACE inhibitor
Beta blocker
For which CVS drug is COUGH a potential side effect ? Morphine Beta Blockers Calcium antagonists Aspirin Nitrates ACE inhibitors
ACE inhibitors
For which CVS drug is TOLERANCE a potential side effect? Bendroflumethazide Beta blockers Calcium antagonist Aspirin Nitrate ACE inhibitor
Nitrate
Which CVS drug is most likely to induce POSTURAL HYPOTENSION as a potential side effect? Morphine Beta blocker Calcium antagonist Aspirin Nitrate ACE inhibitor
Calcium antagonist
Doxazosin is an antagonist at which type of peripheral receptor?
Alpha-1 adrenoceptor
Atenolol is an antagonist at which type of peripheral receptor?
Beta-1 adrenoceptor
The antihypertensive action of lisinopril is due to inhibition of which peripheral enzyme?
Angiotensin Converting Enzyme (ACE)
Which of the following drug side effects is LESS likely to be seen when treating hypertension with an angiotensin receptor blocker (ARB) rather than an ACE inhibitor?
Hyperkalaemia
Cough
Angioedema
Renal failure in the presence bilateral renal stenosis
Cold hands/cold feet
Cough
How do beta-blockers work to relieve the pain from angina pectoris?
Reduce O2 demand by slowing the heart rate
Reduce O2 demand by reducing myocardial contractility
Improve O2 distribution by slowing the heart rate
What is the major mechanism by which glyceryl trintrate can relieve the pain of angina pectoris?
Dilatation of veins to reduce the preload on the heart
Dilatation of arterioles to reduce the after load on the heart
Dilatation of coronary arteries to increase cardiac perfusion
Opening of collateral blood vessels to improve cardiac perfusion
A positive inotropic effect
Dilatation of veins to reduce the preload on the heart
Which of the following drugs is likely to be more suitable for the treatment of variant angina due to coronary artery vasospasm ? Bumetanide Losartan Isosorbide Amlodipine Glyceryl trintrate
Amlodipine
Which of the following drugs might be used to reduce atheromatous disease, the underlying cause of angina pectoris? Atenolol Amlodipine Simvastatin Glyceryl trinitrate Enalapril
Simvastatin
