Quiz 6 (Systematic Reviews and Meta-Analysis)

Question 1

Google Scholar is an appropriate database to search for primary studies.

Answer 1

False

Question 2

In a meta-analysis, the data consists of:

Answer 2

Results from previous studies.

Question 3

When the heterogeneity of a pooled estimate is considered too great, what statistical analysis is appropriate to overcome the distortion to the results?

Answer 3

Subgroup analysis.

Question 4

If the heterogeneity coefficient for the pooled estimate is 0%, we state that there is heterogeneity among the various studies that are included in the calculation of the pooled estimate.

Answer 4

False

Question 5

As a researcher you are interested in investigating the relationship between Traumatic brain injury and Dementia. (PubMed)

1. What two terms would you use to conduct the above search?
2. When you perform the search using the two terms you identified above with no restrictions applied, how many articles do you retrieve?
3. Repeat the search, but this time restrict both terms you identified above to MeSH Major Topic.

How many articles do you retrieve from this search?

4. Keeping both PubMed Headings restricted to Major Topic, how many articles do you retrieve when restricting the search to English-language articles?
5. How many articles do you retrieve when you add limit of male?
6. How many articles do you retrieve when you add limit of age “Middle Aged + Aged: 45+ years”?
7. How many articles do you retrieve when you add limit of 5 years?

Answer 5

1. Traumatic brain injury and dementia
2. 1,353
3. 124
4. 122
5. 57
6. 44
7. 38

Question 6

For pregnant women, what is the relationship between depression and risk of premature birth?

1. What is the study population?
2. What is/are the dependent variable(s)?
3. Is/are the dependent variable(s) categorical or continuous?
4. What is/are the independent variable(s)?
5. Is/are the independent variable(s) categorical or continuous?
6. What is the null hypothesis?
7. What is an alternative hypothesis?
8. Is the alternative hypothesis one-sided or two-sided?

Answer 6

1. Pregnant women
2. Premature birth
3. Categorical
4. Depression
5. Categorical
6. Ho: For pregnant women, there is no association between depression and premature birth.
7. Ha: For pregnant women, a depression diagnosis increases the risk of premature birth.
8. 1-sided