Quiz 5 (second half) Flashcards
what does Phlegmasia mean?
greek word phlegma meaning inflammation
what does PAD stand for?
Phlegmasia alba dolens
what is Phlegmasia alba dolens used for?
in the medical literature in reference to extreme cases of lower-extremity deep venous thrombosis (DVT) that cause critical limb ischemia and possible limb loss
what does Phlegmasia alba dolens (PAD) describe?
the patient with swollen and white leg becuase of early compromise of arterial flow secondarty to extensive DVT
what is Phlegmasia alba dolens also known as?
milk leg
who does milk leg effect?
women in the third trimester of pregnancy or post partum
what does PCD stand for?
Phlegmasia cerulean dolens
when is the diagnosis of phlegmasia alba dolens (PAD) or phlegmasia cerulaea dolens (PCD) made?
clinical grounds in patients who have extensive DVT on imaging
is PAD or PCD more advanced?
Phlegmasia cerulea dolens (PCD)
what is PCD considered a precursor for?
frank venous gangrene
what is PCD characterized by?
severe swelling and cyanosis and blue discoloration of the extremity
points to remember about Phlegmasia alba dolens?
- known as milk leg or white leg
- blanching of extremities, edema, and discomfort
- leg is pale and cool
- diminished arterial pulse due to spasm
points to remember about Phlegmasia cerulen dolens?
- painful blue edema
- pain and cyanosis
- DVT in deep, superficial and collateral veins
- extends into capillaries 40-60% of the time
- irreversible ischemia, necrosis and gangrene
- surgical emergency
what is Trousseau’s sign?
concerns hypercoagulability associated with cancer
what is DVT in occult malignancy based on
the finding of spontaneous venous thrombosis in patients with underlying malignancy
what us a concern when patients present with DVT and have no known risk factors?
they may have an occult malignancy
is DVT with or without malignancy more extensive and aggresive?
DVT associated with malignancy
what does DVT malignancy clinincaly demonstrate?
a very swollen and painful extremity
Patients with DVT related to Trousseau’s syndrome usually clinically manifest cancer within ____________
1-2 years
where do malignancies associated with venous thrombosis typically arise in?
- breast
- GI tract
- GU tract
- lung
- brain
why can detection of thrombus in the SVC be difficult?
due to the frequency of it occuring centrally in the vein
what makes compression impossible for the SVC?
overlying bones (clavicle)
what does diagnosus of subclavian vein obstruction rely on?
secondary signs of obstruction
what does the SCV look like on spectral?
close to the right atrium, so pressure flucuations in the atrium are readily tramsitted into the vein, producing a pulsatile waveform
when is the normal pulsatility of subclavian vein obstruction blunted?
when there is a venous obstruction between the heart and the site where doppler waveform is obtained
what is diagnostic for subclavian vein obstruction?
demonstrating the asymmetry between the right and left SVC waveform
what should be apart of the SVC thrombosis examination?
many involve IJV thrombosis
what should be a potential cause in subclavian vein obstructon?
extrinsic compression as in large lymoh nodes due to breast cancer
if the SVC is the site of obstruction, what may occur?
collateral flow in the internal mammary veins may occur (flow appears reversed)
what is Lemierre’s syndrome?
jugular vein thrombosis
where do we see Lemierre’s syndrome?
in a patient with a neck infection and enlarged lymph nodes
what does IJV compression result in?
thrombus formation due to stasis
what is behcet’s disease/syndrome?
inflammation in blood vessels (veins and arteries)
what is the etiology of behcet’s disease/syndrome?
unknown or is autoimmune (bodys immune system attacks healthy cells)
what does behcet’s disease/syndrome cause in the arms and legs?
redness, pain, and swelling in the arms and legs
what can behcet’s disease/syndrome cause in the vessels?
blood clot to form
what can imflammation in large arteries lead to?
complications such as aneurysms or blockage of a vessel
what else does behcet’s disease/syndrome affect?
mouth, skin, genitals, eyes, joints, digestive system and the brain (causeing a stroke)
The etiology of IVC thrombus mirrors what?
that of DVT in general
what does IVC thrombus relate to?
specific situations relate to the IVC only but the wide variety of these situations all relate in one or more ways to VIRCHOWS CLASSIC DESCRIPTION
Virchow’s classic description
- wall damage
- hypercoagulability
- venous stasis
what are numerous malignancies associated witha?
IVCT (IVC thrombus)
what is the most familar malignancy associated with IVCT?
renal cell carcinoma
what is the path of spread of RCC?
the intravascular tumor extends from the renal vein and can propagate as far as the heart
what are Other genitourinary tumors that reportedly cause IVCT?
seminomas and teratomas
what can any structure that is anatomically related to the IVC generate?
either a direct compression or vascular invasion
what have all presented in association with IVCT?
- retroperitoneal leiomyosarcoma
- adrenal cortical carcinoma
- renal angiomyolipooma
hepatic hemagioma has caused IVCT from __________
extrinsic compression
what is a risk factor for DVT and the extension into the IVC?
malignancy itself
what may extrinis compression result from?
nontumoral sources and increase the likelihood of IVCT