Quiz 5

Question 1

1. Understand the role of kidneys in the treatment of CHF

Answer 1

s

Question 2

2. List the site of action eg diuretics on the kidney nehron

Answer 2

s

Question 3

List 3 classes of anti-anginal drugs and give an example of each

Answer 3

1. The organic nitrates eg glycerol trinitrate
2. Calcium channel blocker eg Nifedipine
3. B blockers (contraindicated for variant angina)

Question 4

List the examples of calcium channel blockers used to treat angina

Answer 4

Nifedipine

Verapamil

Question 5

List with examples the beta blockers used to treat angina

Answer 5

Propranolol

Metoprolol

Question 6

Pharmalogical strategies for combating primary hypertension

Diuretics:

Answer 6

1. Thiazide diuretics
   - inhibit Na+ and Cl- reabosrption in distal tubule–> water retention)
   - decrease blood colume
   - cheap and slow onset of action
   eg: Chlorothiazide, bendrofluazide

Adverse effects:
-loss of potassium, uric acid retention, impotence, dizziness,

2. Loop Diuretics:
   Inhibit Na, K, Cl transport in ascending loope of henle
   -results in retention of of the above and water in the tubule
   Results in decreased renal vascular resistance and increased renal blood flow
   -loop diuretics are most efficacous of diuretics
   Therapeutic uses: reduces pulmonary oedema on CHF

Adverse effects: potassium depletion, otooxicity
examples:
-bumetanide
-furosemide