QUIZ 5

Question 1

For Qs 1-3, consider mutations that contribute to cancer. If the wild-type version of a gene promotes cell proliferation, what mutation genotype would likely be found in cancer? (gf means gain of function, if means loss of function and + means wildtype allele of the gene)

Answer 1

gf/+

Question 2

If the wild-type of a haplo-sufficient gene keeps cells in G0/G1 until conditions are right for cell proliferation, what mutant genotype would likely be found in cancer?

Answer 2

If/If

Question 3

if the wild-type version of a halpo-insufficient gene keeps cells in G0/G1 until conditions are right for cell proliferation, what mutant genotype would likely be found in cancer?

Answer 3

If/+

Question 4

what is the genotype of a blood cell (NOT a cell in the eye) in individual II-3 from pedigree A? (gf means gain of function, If means loss of function and + means wildtype allele of the gene)

Answer 4

Rb+/Rb(If)

Question 5

In a certain pathway, gene A homozygous mutants are purple. Gene B homozygous mutants are pink. From a dihybrid cross involving the A and B genes, the following offspring colors are observed; 93 gold, 29 purple, and 41 pink. Think about the order of colors in the pathway and the order of gene action. Which gene is responsible for producing purple?

Answer 5

B

Question 6

For Qs 7-10, the gurken gene (G) and the runt gene (R) are both required for proper development of the Drosophila embryo; both genes are haplosufficient. G is a maternal effect gene and R is a zygotic gene. For each of the crosses below, indicate what percentage of progeny will not develop properly and die.

Mom is g/g and dad is G/G. Put a number in the box

Answer 6

100

Question 7

Mom is G/g and dad is g/g. Put a number in the box

Answer 7

0

Question 8

Mom is R/r and dad is R/r. Put a number in the box.

Answer 8

25

Question 9

Mom is R/r and dad is R/R. Put a number in the box.

Answer 9

0