quiz 3 Flashcards
PGI2
- vasodilation
- inhibits platelet aggregation
- released from endothelieal cells
- antagonist of TXA2
PGD2
- increase number of mast cells
- bronchospasm
- decrease hair growth
- allergic reactions
- recruits eosinophils
PGE2
- vasodilation
- potentiate edema
- fever
- hyperalgia
- uterine contraction/cervix relax for labor
PGF2
- corpus letum
- luteolysis
- stops production of progesterone
- induces labor
TXA2
- vasoconstriction
- promotes platelet aggregation
- produced by platlets
- antagonist of PGI2
Cyclooxygenase
-takes free arachidonic acid and makes prostaglandin G2, then H2
phospholipases
- creates arachidonic acid
- inhibited by steroids
prostaglandin G2
- first subset of prostagladins after cyclooxygenase
- vascular component of inflammation
- produced by blood cells
5-lipoxygenase
takes free arachidonic acid and produces leukotrienes
leukotrienes
- vasoconstriction
- bronchospasm
- increased permeability
Lipoxin
- created by 12-lipoxygenase
- vasodilation
- inhibit neutrophil chemotaxis
- stimulate monocyte adhesion
vascular component of inflammation
- hyperemia
- increased vessel permeability
benefits of exudate
- dissolution of toxin
- promotion/accumulation antibodies
- stimulation of nociceptors
- promotion of phagocytosis
steps of vascular inflammation
- vasoconstriction (arteriolar)
- vasodilation of capillary
- exudate pushed out of cell
- blood viscosity increase creating stasis
- increased permeability of vessels increase is osmotic pressure of tissue
steps of cellular inflammation
- margination (WBC move to vessel edges since RBCs are increasing in size due to clumping)
- rolling
- adhesion(chemical linkage)
- pavementing
- emigration (actively leaves, only in venules, 10 min)
- chemotaxis
- engulfment/destruction
opsonization
-WBC using a chemical mediator to attach to toxin (ex. antibody)
phagosome
when WBC engulfs antigen
degranulation
-WBC has lost its lysosomes and vesicles bc it ate an antigen
diapedesis
- when RBCs passively leave cell
- this is different than Emigration because that is active
oxygen Independant lysosomal mechanisms
- lysozyme
- elastase
- collagenase
- defensin
oxygen Dependant
- produce free radicals
- superoxide anion
- hypochlorite anion
- hydrogen peroxide
chronic granulomatous disease
- children
- body creates granuloma around invading microbe
- Ghons Focus
- body unable to prevent infection
- death by 2
Chediak- Higashi syndrome
- genetic absence of normal cell motility of phagocytes
- inability to release lysosomal enzymes
- death 1-2 years
nitric oxide aka
endothelial derived relaxing factor
biochemical cascade
- coagulation
- fibrinolytic
- complement
- kinin
bradykinin
-irritate chemoreceptors, creating peception of pain
complement
- participate in inflammatory response
- potentiates function of histamine
