quiz 3 Flashcards
Which of the following is CORRECT regarding B-lymphocyte development?
Question 1 Answer
a.
IL-7 guides development from hematopoetic stems cells (HSC) into the lymphoid linage.
b.
B-lymphocytes are released as mature but naïve lymphocytes from the Bone marrow.
c.
B-lymphocytes develop from common lymphoid progenitor cells in the thymus.
d.
B-lymphocytes reach full maturity once activated in a lymphoid follicle.
a.
IL-7 guides development from hematopoetic stems cells (HSC) into the lymphoid linage.
Which of the following cytokines, secreted by Th2 cells, promote class switching to IgE?
Question 2 Answer
a.
IL-4 & IL-5
b.
TGF-Beta
c.
IL-1
d.
INF-gamma
a.
IL-4 & IL-5
Which co-stimulatory interaction between B-cell and follicular T helper cell is needed to induce cytokine production by the follicular T helper cell for B-cell activation?
Question 3 Answer
a.
iCOSL (B-cell) and iCOS (T helper cell)
b.
CD40 (B-cell) and CD40L (T helper cell)
c.
CD80/86 (B-cell) and CD28 (T helper cell)
d.
HLA-2 (B-cell) and TCR (T helper cell)
a.
iCOSL (B-cell) and iCOS (T helper cell)
Choose the TRUE statement regarding the activity of IgM
Question 4 Answer
a.
IgM is poor at activating complement
b.
IgM is secreted as a dimer, and can bind 4 separate antigens
c.
IgM is not secreted - it only has a role as the B cell receptor
d.
IgM is good at immobilizing pathogens so that they can be phagocytosed
d.
IgM is good at immobilizing pathogens so that they can be phagocytosed
Which area of a lymph node contains predominantly B-lymphocytes?
Question 5 Answer
a.
Paracortex
b.
Reticular capsule
c.
Medulla
d.
Cortex
d.
Cortex
What is the function of a Langerhans cell?
Question 6 Answer
a.
It recognizes bound IgE via its Fc receptor and releases histamine and proteases.
b.
It activates mast cells by migrating to the lamina propria and releasing IL-33.
c.
It presents antigens obtained via phagocytosis in secondary lymphoid organs.
d.
It destroys bacteria through the process of phagocytosis and free radical generation
c.
It presents antigens obtained via phagocytosis in secondary lymphoid organs.
Choose the FALSE statement regarding the itching associated with atopic dermatitis.
Question 7 Answer
a.
ILC1 excitation and release of IL-18 causes sensitization of C-type nerve endings, increasing itch.
b.
Filaggrin deficits and scratching cause loss of moisture from the skin, which can exacerbate itch.
c.
Sprouting of neuronal C-type nerve endings in the epidermis and dermis is associated with increased itching.
d.
Histamine and TSLP can stimulate the sensation of itching.
a.
ILC1 excitation and release of IL-18 causes sensitization of C-type nerve endings, increasing itch.
Which of the proteins below is MOST often associated with atopic dermatitis when its function is impaired?
Question 8 Answer
a.
Claudin
b.
Occludin
c.
Filaggrin
d.
Zonulin
c.
Filaggrin
Which of the following is a function of leukotrienes?
Question 9 Answer
a.
Smooth muscle constriction.
b.
Polarization of a naive Th to a Th2 cell.
c.
Stimulation of eosinophil proliferation and activation.
d.
Activation of ILC1 cells.
a.
Smooth muscle constriction.
Choose the TRUE statement regarding IgE.
Question 10 Answer
a.
IL-10 is the major cytokine that stimulates class switching to IgE.
b.
IgE secretion is typical of a Th17 response.
c.
IgE is secreted across mucosal barriers and serves to inactivate helminth species (worms).
d.
IgE serves as an effector when it is bound to the Fc receptor of granulocytes.
d.
IgE serves as an effector when it is bound to the Fc receptor of granulocytes.
Choose the cytokine that is most likely to be secreted by an alternatively-activated (M2) macrophage.
Question 11 Answer
a.
IL-10
b.
IL-23
c.
IL-8
d.
IL-33
a.
IL-10
A person develops antibodies that stimulate the TSH receptor - she develops hyper-thyroidism because of activation of the receptor. What type of hypersensitivity reaction is most likely occurring?
Question 12 Answer
a.
Type IV
b.
Type I
c.
Type II
d.
Type III
c.
Type II
A person with multiple sclerosis receives a medication that prevents the migration of cytotoxic T-cells into the central nervous system. What type of hypersensitivity is this patient likely experiencing?
Question 14 Answer
a.
Type III
b.
Type I
c.
Type IV
d.
Type II
c.
Type IV
What type of cell is most likely to be found within a granuloma?
Question 15 Answer
a.
A neutrophil
b.
A dendritic cell
c.
A lymphocyte
d.
An eosinophil
c.
A lymphocyte
A person with a peanut allergy consumes a granola bar that contains traces of peanuts. He rapidly develops facial swelling, hives, and shortness of breath. What type of hypersensitivity reaction is most likely occurring?
Question 13 Answer
a.
Type II
b.
Type III
c.
Type IV
d.
Type I
d.
Type I
