Quiz 2 BB Lec: Blood Group Clinical Significance

Question 1

Rh-null RBC anomaly

Answer 1

stomatocytosis

Question 2

RBC abnormalities & MUSCULAR disease

Answer 2

McLeod syndrome (Kell group)

Question 3

DHTR

Answer 3

Kidd

Question 4

resists lysis in 2M urea

Answer 4

Jk(a-b-)

Question 5

weak antibodies, rare transfusion reactions

Answer 5

Lutheran

Question 6

effect of Lu(a-b-)

Answer 6

no clinical effect

Question 7

what type of Transfusion rxn happens with Diego

Answer 7

Mild

Question 8

Most Common in Asians & Native Americans

Answer 8

Diego

Question 9

Rare but severe Transfusion reactions.

Answer 9

Colton

Question 10

Aquaporin-1 deficiency linked to dehydration disorders.

Answer 10

Colton

Question 11

Gerbich-negative significance

Answer 11

malaria resistance

Question 12

Disappears in pregnancy

Answer 12

Lewis

Question 13

PCH; PNH

Answer 13

P; Cromer

Question 14

Receptor for Parvovirus B19

Answer 14

P antigen

Question 15

Cold agglutinin disease

Answer 15

I

Question 16

Anti-I (disease ass)

Answer 16

Mycoplasma pneumoniae

Question 17

Anti-i (disease ass)

Answer 17

EBV

Question 18

complement receptor dysfunction

Answer 18

knops

Question 19

CD55 mutation linked to PNH

Answer 19

cromer

Question 20

Plasmodium vivax receptor (Malaria)

Answer 20

Duffy

Question 21

Receptor for Parvovirus B19 (Aplastic crisis)

Answer 21

P

Question 22

linked to chronic granulomatous disease (CGD)

Answer 22

Kell

Question 23

Autoimmune diseases (due to CR1 dysfunction)

Answer 23

Knops

Question 24

Blood Groups with High HDFN Risk

Answer 24

Rh, Kidd, Kell, Duffy

(all are IgG, all are proteins, most have double letters)

Question 25

Blood groups with LOW HDFN risk

Answer 25

L,I,P (carb based, less immunogenic, IgM)

Question 26

Which gprotein groups are destroyed by enzymes?

Answer 26

all protein-based except Kidd & MNS

Question 27

most common cause of HDFN

Answer 27

Duffy

Question 28

"disappearing antibody"

Answer 28

Kidd