Quiz 2 Flashcards
What is the enzyme that converts gln –> glut in the mitochondria?
glutaminase
What is the enzyme that converts asp –> glut outside the mitochondria?
transaminase
What is the enzyme that degrades glut –> gln in the glia?
glutamine synthase
What is the transporter that takes up glut back into the cell?
EAAT 1 - 3
What mechanism is responsible for packaging glut into vesicles?
Mg2+/ATP-dependent h+ gradient pump
How does NMDAR act as a coincidence detector?
When two neurons fire at the same time, Mg2+ unplugs and activates
What is neuroligin?
a type I membrane protein, is a cell adhesion protein on the postsynaptic membrane that mediates the formation and maintenance of synapses between neurons. Neuroligins act as ligands for β-Neurexins, which are cell adhesion proteins located presynaptically.
What enzyme converts glutamate to GABA?
glutamic acid decarboxylase
What is the main intracellular protein involved in NMDA-dependent LTP?
Ca2+, CaMKII, receptor insertion
What is the main intracellular protein involved in NMDA-dependent LTD?
Ca2+, PPP1, Calcineurin, receptor internalization
What is the main mechanism involved in mGluR-dependent LTD?
receptor internalization
What is the main intracellular protein involved in presynaptic-LTP?
Ca2+, AC. cAMP, PKA…more NT release
What is the main intracellular protein involved in eCB-LTD?
mGluR PLC activation together with Ca2+ produces eCB that releases and bind to CB1 autoreceptor and prevent further NT release
Where is the largest nor adrenergic nucleus located?
locus ceruleus
What disease does B1-adrenergic antagonists target?
Cardiovascular Disease
What disease does B2-adrenergic antagonist target?
Asthma
What receptor does Propranolol target and what is its role?
Beta 1 and beta 2 adrenergic receptor antagonist
What is the function of presynaptic alpha 2 adrenergic receptors?
autoreceptor that inhibits activity in cell bodies by blocking the release of more NTs
What structure does Reserpine inhibit?
VMAT, vesicular monoamine transporter. Stops the packaging of NTs (ALL MONOAMINES) into cells
What structure does Tolcapone inhibit?
COMT, stops the breaking down of monoamine
What function does AMPT inhibit?
the synthesis of DA, NE, AND EP by the inihibition of tyrosine hydroxylase
What are NRI/SNRI
Norepinephrine reuptake inhibitor
Which MAO does selegiline target?
MAOB for dopamine
Which MAO does MAOI target?
MAOA for NE ans 5-HT
What is the function of PCPA
inhibit synthesis of serotonin by inhibition of tryptophan hydroxylase
What receptors do many anti-psychotic drugs target?
5HT2A
antimigrain triptans are agonists for what receptors?
5-HT 1D and 1B
What is the brand name for fluoxetine?
prozac
What are the characteristics of MAT receptor domain?
intracellular N-C terminus
12 hydrophic TM domains
