Quiz 2

Question 1

What is the enzyme that converts gln –> glut in the mitochondria?

Answer 1

glutaminase

Question 2

What is the enzyme that converts asp –> glut outside the mitochondria?

Answer 2

transaminase

Question 3

What is the enzyme that degrades glut –> gln in the glia?

Answer 3

glutamine synthase

Question 4

What is the transporter that takes up glut back into the cell?

Answer 4

EAAT 1 - 3

Question 5

What mechanism is responsible for packaging glut into vesicles?

Answer 5

Mg2+/ATP-dependent h+ gradient pump

Question 6

How does NMDAR act as a coincidence detector?

Answer 6

When two neurons fire at the same time, Mg2+ unplugs and activates

Question 7

What is neuroligin?

Answer 7

a type I membrane protein, is a cell adhesion protein on the postsynaptic membrane that mediates the formation and maintenance of synapses between neurons. Neuroligins act as ligands for β-Neurexins, which are cell adhesion proteins located presynaptically.

Question 8

What enzyme converts glutamate to GABA?

Answer 8

glutamic acid decarboxylase

Question 9

What is the main intracellular protein involved in NMDA-dependent LTP?

Answer 9

Ca2+, CaMKII, receptor insertion

Question 10

What is the main intracellular protein involved in NMDA-dependent LTD?

Answer 10

Ca2+, PPP1, Calcineurin, receptor internalization

Question 11

What is the main mechanism involved in mGluR-dependent LTD?

Answer 11

receptor internalization

Question 12

What is the main intracellular protein involved in presynaptic-LTP?

Answer 12

Ca2+, AC. cAMP, PKA…more NT release

Question 13

What is the main intracellular protein involved in eCB-LTD?

Answer 13

mGluR PLC activation together with Ca2+ produces eCB that releases and bind to CB1 autoreceptor and prevent further NT release

Question 14

Where is the largest nor adrenergic nucleus located?

Answer 14

locus ceruleus

Question 15

What disease does B1-adrenergic antagonists target?

Answer 15

Cardiovascular Disease

Question 16

What disease does B2-adrenergic antagonist target?

Answer 16

Asthma

Question 17

What receptor does Propranolol target and what is its role?

Answer 17

Beta 1 and beta 2 adrenergic receptor antagonist

Question 18

What is the function of presynaptic alpha 2 adrenergic receptors?

Answer 18

autoreceptor that inhibits activity in cell bodies by blocking the release of more NTs

Question 19

What structure does Reserpine inhibit?

Answer 19

VMAT, vesicular monoamine transporter. Stops the packaging of NTs (ALL MONOAMINES) into cells

Question 20

What structure does Tolcapone inhibit?

Answer 20

COMT, stops the breaking down of monoamine

Question 21

What function does AMPT inhibit?

Answer 21

the synthesis of DA, NE, AND EP by the inihibition of tyrosine hydroxylase

Question 22

What are NRI/SNRI

Answer 22

Norepinephrine reuptake inhibitor

Question 23

Which MAO does selegiline target?

Answer 23

MAOB for dopamine

Question 24

Which MAO does MAOI target?

Answer 24

MAOA for NE ans 5-HT

Question 25

What is the function of PCPA

Answer 25

inhibit synthesis of serotonin by inhibition of tryptophan hydroxylase

Question 26

What receptors do many anti-psychotic drugs target?

Answer 26

5HT2A

Question 27

antimigrain triptans are agonists for what receptors?

Answer 27

5-HT 1D and 1B

Question 28

What is the brand name for fluoxetine?

Answer 28

prozac

Question 29

What are the characteristics of MAT receptor domain?

Answer 29

intracellular N-C terminus

12 hydrophic TM domains