Quiz 2 Flashcards
_ is the phenomenon whereby anticipation and expectation of a negative outcome may induce the worsening of a symptom.
NOCEBO
What do anterior cingulate cortex, prefrontal cortex, Thalamus, basal ganglia, insular cortex, amygdala, and periaqueductal grey matter have in common?
They all have mu-opioid receptors
What area of the brain is associated with: recognition/ awareness? Decision making/ thought process? Considered the relay center?
Recognition/ awareness= anterior cingulate cortex (ACC)
Decision making/ thought process= prefrontal cortex (PFC)
Relay center= Thalamus
What area of the brain is responsible for: gut feeling? Emotion/ feeling ‘happy’? Serotonin production?
Gut feeling= insular cortex
Emotion/ feeling happy= amygdala
Serotonin production= periaqueductal grey matter
Morphine, oxycodone (Percocet, OxyContin), and hydrocodone (Vicodin, codeine) are examples of? Can affect more than _, also has an effect on _ and _ _. (Which correspond to which areas of the brain?)
All are examples of ANALGESICS
Can effect more than PAIN, also has an effect on COGNITION (PFC) and MOTOR FUNCTION (BASAL GANGLIA)
Dopamine (D1-5) receptors are found in the _ _, ventral tegmentum, and striatum.
. . . Are found in the BASAL GANGLIA, ventral tegmentum and striatum
Cocaine, ecstasy, amphetamines, and methamphetamines are examples of _ _ _. What is the prescription drug version (NDRI’s) used for? Dopamine agents _ nociception.
. . . Are all examples of DOPAMINE REUPTAKE INHIBITORS
Prescription drug version is NDRI’s (norepinephrine and dopamine reuptake inhibitors) used as anti-depressant (example- Wellbutrin)
Dopamine agents ATTENUATE nociception
In addition to the Basal ganglia, serotonin is also released in the _ _, and _ _.
. . . Serotonin is also released in the BRAIN STEM, and GASTROINTESTINAL TRACT
_ and _ _ _ (Effexor, cymbalta), and _ _ _ _ (selective serotonin reuptake inhibitors) are prescribed for anti-depressants, anti-anxiety, and for chronic pain relief.
SEROTONIN and NOREPINEPHRINE REUPTAKE INHIBITORS (SNRI’s) and SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRI’s) are prescribed . . .
In addition to having a patient rate his/ her pain intensity on a scale from 0-10 what additional scaled information might be useful?
How unpleasant/ taxing/ annoying/ debilitating (etc) is your pain?
_ have been found to activate pain modulating networks. What is the is known as?
EXPECTATIONS have been found to . . .
Known as the PLACEBO EFFECT
Where is the reward system of the brain located?
Nucleus accumbens
Placebo analgesia affects pain via both _ of ascending nociceptive pathways and _ of forebrain and limbic pain generating circuits.
Placebo analgesia affects pain via both INHIBITION of ascending nociceptive pathways and MODULATION of forebrain and limbic pain generating circuits.
There are _ _ _ that make up the cortical mechanisms of placebo analgesia.
There are 3 DESCENDING PATHWAYS that make up . . .
What are the stops on the first descending placebo pathway (3)?
APP
- anterior cingulate cortex (ACC)
- prefrontal cortex (PFC)
- periaqueductal grey matter (PAG)
The second descending placebo pathway includes which 5 structures?
D PAIR (order)
- Dorsal horn (5)
- PAG (3)
- Amygdala (2)
- INSULA (1)
- Rostral ventral medulla in the brain stem (4)
Placebo in clinical practice: include _ suggestions about treatment _; _ _ and feel of _ affect patient perception of office competency and ‘buy in’; communicate _ a _ _ _ is being used.
Include POSITIVE suggestions about treatment EFFICACY
OFFICE ENVIRONMENT and feel of TREATMENT affect patient perception of office competency and ‘buy in’.
Communicate WHY a PARTICULAR THERAPEUTIC APPROACH is being used