Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

ImmunoSero 3rdYR 1stSem Prelims > Quiz 2 > Flashcards

Quiz 2 Flashcards

1
Q

important cells of the adaptive or acquired immunity because they are activated to produce various responses depending on the type of antigen the immune system is facing

A

T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Cell infected with intracellular antigen such as bacteria or virus

A

Target Cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Target cells are targeted and killed by what cells

A

Cytotoxic T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

T cells that migrate to the thymus

A

Progenitor T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Part of Thymus with earliest development of T cells

A

Cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Where T cell positive selection happens

A

Thymus Cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Part of thymus where later events of T cell development happen

A

Medulla

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Where T cell negative selection happens

A

Medulla

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

T cells that still do not express signature surface markers

A

Precursor T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Precursor T cells are aka?

A

Double Negative Thymocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Signature T cell surface markers

A

CD4, CD8, CD3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Precursor T cells do not express these

A

CD4, CD8, RAGs 1, RAGs 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Thymocytes that then posses markers such as CD4 and CD8 are aka?

A

Double Positive Thymocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

When Double Positive Thymocytes undergo positive selection, they become?

A

Single Positive Thymocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

When Double Positive Thymocytes attach to MHC I, they become?

A

CD8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

When Double Positive Thymocytes attach to MHC II, they become?

A

CD4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

If single positive thymocytes that bear CD4 attach themselves to MHC II or CD8 to MHC I, what will happen

A

Apoptosis (interacting with self antigens)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

If single positive thymocytes have moderate to no response, what happens?

A

Release into Circulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Set of molecules displayed on a cell surface that are responsible for lymphocyte recognition and antigen presentation

A

Major Histocompatibility Complex (MHC)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Control mechanism of the immune response by the recognition of “self” and “non-self” antigens

A

Major Histocompatibility Complex (MHC)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Transcription factor expressed in the medulla of the thymus and controls the mechanism that prevents the immune system from attacking the body itself

A

Autoimmune Regulatory Gene (AIRE)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Loss of AIRE gene will result in?

A

Autoimmune disorders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

How many light chains does an antibody have

A

2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

How many heavy chains does an antibody have

A

2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Surface marker of Stem Cell

A

CD43

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Surface marker of Pro-B cell

A

CD43
CD19
CD10

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Surface marker of Pre-B cell

A

Low B220
CD43

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Surface marker of Immature B cell

A

Low IgM
CD43

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Surface marker of Mature B cell

A

IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Responsible for B cells to undergo recombination in order for it to express diversity

A

Recombination Activating Gene (RAG)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

B cells with only IgM as its immunoglobulin

A

Immature B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

B cells with both IgM and IgD as its immunoglobulins

A

mature B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Mature B cells are released into the circulation as?

A

Naive B Cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Once Naive B cells encounter antigen, they become?

A

Plasma cells & Memory B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Production of antibody is aka?

A

Humoral Immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

IgM stands for?

A

Immunoglobulin Mue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

IgE stands for?

A

Immunoglobulin Epsilon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

IgG stands for?

A

Immunoglobulin Gamma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

IgA stands for?

A

Immunoglobulin Alpha

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

IgD stands for?

A

Immunoglobulin Delta

41
Q

2 phases of differentiation for B cell maturation

A

Antigen-independent Phase (Bone Marrow)
Antigen-dependent Phase (Peripheral Lymphoid Tissues / Brain)

42
Q

phase of differentiation for B cell maturation:

Interaction of Naive B cell with Antigen (Mature B cell to Plasma Cell)

A

Antigen-dependent Phase

43
Q

4 subdivisions of Heavy Chains

A

Variable (V)
Diversity (D)
Joining genes (J)
Constant (C)

44
Q

Most common method of removing self-reactive B cells

A

Receptor Editing

45
Q

Under the Electron Microscope, B cell appears what

A

Hairy

46
Q

Allows for the multiplication of B cells

A

Mitogen

47
Q

Chemical substance that encourages a cell to commence cell division triggering mitosis

A

Mitogen

48
Q

cause of Hairy appearance of B cells under Electron Microscope

A

Surface Immunoglobulins

49
Q

Do T cells appear hairy under an Electron Microscope?

A

No

50
Q

An enzyme which helps the precursor of b cell to transform into immature B cell

A

Bruton’s Tyrosine Kinase

51
Q

Characterized by the failure of B cell precursors to mature into B cells in the peripheral blood

A

Bruton’s X linked Agammaglobulinemia

52
Q

Bruton’s X Linked Agammaglobulinemia is due to the mutation of the genes that encode for what enzyme

A

Tyrosine Kinase Enzymes

53
Q

CD Markers of B cells

A

CD19
CD20
CD21

54
Q

CD marker that is the receptor for Epstein Barr virus

A

CD21

55
Q

Group of functionally defined cells capable of taking up antigens and presenting them to lymphocytes in a form of that they can recognize

A

Antigen Presenting Cells (APCs)

56
Q

2 pathways of antigen processing

A

Endogenous
Exogenous

57
Q

Which antigen processing pathway is CD8 Tc Cell + MHC I

A

Endogenous

58
Q

Which antigen processing pathway is CD4 Th Cell + MHC II

A

Exogenous

59
Q

All nucleated cells except _____ are capable of antigen presentation

A

RBCs

60
Q

Where does Endogenous Pathway occur

A

Endoplasmic Reticulum

61
Q

Where does Exogenous Pathway occur

A

Endosome

62
Q

All cells that have a nucleus are MHC I except?

A

RBCs

63
Q

MHC II are only in what type of cells

A

Macrophages
B cells
Dendritic Cells

64
Q

Type of Antigen of MHC I

A

Intracellular (Endogenous)

65
Q

Type of Antigen of MHC II

A

Exrtacellular (Exogenous)

66
Q

MHC I is recognized by?

A

CD8 T cytotoxic Cell

67
Q

MHC II is recognized by?

A

CD4 T helper Cell

68
Q

Most potent phagocytic cell in the tissue

A

Dendritic Cells

69
Q

Where are dendritic cells found

A

Lymph Nodes

70
Q

Main function of Dendritic Cells

A

Antigen Presenting Cell to T helper cells

71
Q

Two subunits of Dendritic Cells

A

Interstitial (major organs)
Interdigitating (T lymphocytes of Secondary Lymphoid Organs & Thymus)

72
Q

Subunit of Dendritic Cells that can act as a messenger between the innate and adaptive immune system

A

Interdigitating Dendritic Cells

73
Q

Recognition of Antigen is by what Surface Marker of the T cell?

A

CD3

74
Q

Extracellular antigens are presented by?

A

MHC II

75
Q

Presented antigen is recognized by the T cell receptor with what surface marker?

A

CD3

76
Q

MHC II is recognized by what marker of the T cell?

A

CD4

77
Q

CD stands for

A

Classification Determinant

78
Q

CD Marker present in all T cells and has a “rosette formation” in combination with SRBCs

A

CD2

79
Q

pan-T cell marker

A

CD2

80
Q

CD marker that recognizes antigen during presentation

A

CD3

81
Q

New pan-T cell marker

A

CD3

82
Q

Which T cells contain CD3

A

All

83
Q

Recognizes only MHC I

A

CD8

84
Q

CD4 is only present in what T cell

A

T helper Cell

85
Q

CD8 is only present in what T cell

A

T cytotoxic Cell

86
Q

CD markers for the identification of B cells

A

CD19
CD 20

87
Q

CD marker that serves as the receptor for Epstein Barr virus in B lympocytes

A

CD21

88
Q

CD markers seen in Natural Killer Cells (NK)

A

CD 16
CD 56
CD 57

89
Q

The structures, cells, and soluble constituents of the circulating blood that allow the host to recognize and respond to antigens

A

Immune System

90
Q

Which immunoglobulin is first to increase in Primary Response

A

IgM

91
Q

Why is IgM the first to increase in Primary Response

A

it is Pentameric (more antigens can bind to it)

92
Q

Which immunoglobulin is first to increase in Secondary Response

A

IgG

93
Q

Another name for Secondary Response

A

Anamnestic Response

94
Q

Anamnestic Etymology

A

Greek word which means Remembrance

95
Q

Which T cell functions to induce antibody production

A

T helper II cell

96
Q

Small Peptides are presented to T helper cells via?

A

MHC II

97
Q

Control mechanism to ensure that mature thymocytes are capable to distinguish self from nonself

A

Negative Selection

98
Q

phase of differentiation for B cell maturation:

Pro B Cell to Immature B cells

A

Antigen-Independent Phase

ImmunoSero 3rdYR 1stSem Prelims (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions