quiz Flashcards
Implantation of blastocyte
day 12 post fertilization
day 26 of menstrual cycle
USUALLY corpus luteum is degenerating, and LH, E, and P are declining and endometrium functional layer sloughs off
hCG
human chorionic gonadotropin
- made by syncytiotrophoblast cells and placenta
- acts like LH
- keeps corpus luteum from degenerating
- E and P stay high
-E and P maintenance of endometrium is from corpus luteum at first, with help from LH and hCG, but placenta takes over E and P by end of 1st trimester
how to tell if pregnant
presence of hCG
- Immunoassay pregnancy test:
- antibody against hCG is mixed with urine or blood and positive reaction occurs when antibody binds to hormone
- home pregnancy tests are super accurate is taken one week after missed period
Amniocentesis
- week 14-16
- if mom is over 34 or there’s fam history
- needle into amniotic fluid to sample fetal cells
- risks: uterine hemorrhage, fetal trauma, miscarriage, preterm labor
Chorionic villus sampling
ultrasound
maternal blood sampling
- week 8-10 –> chorionic cells removed from placenta through vaginal entry –> earlier results (1 day), but fewer details –> greater risk of miscarriage than amniocentesis
- heart rate can be seen at 6 weeks and heard by 8 weeks, measurements and sex determination
- analysis of hormones and prots –> also presence of fetal cells
fetal/maternal cell transfer
- fetal cells in mom or mom cells in fetus
- fetal cells in mom might cause autoimmune disease (more common in women) –> fetal cells attack host and/or host attacks fetal cells
nutrition and excercise while pregnant
-more energy demands
-prenatal vitamins: folic acid for nervous system, protein, calcium, iron –> start taking before pregnant
-exercise is good
-25 lbs weight gain:
baby = 7
amniotic fluid = 1
breast and uterus = 3
placenta = 2
blood = 1
fat = 11
functions of pregnancy hormones and when does secretion start
- maintain pregnancy
- prepare for delivery
- prepare for breastfeeding
placenta secretes hormones ~ 5 weeks -> E + P increases –> fetal hormones play a role in E + P production
E and P role in pregnancy
E:
- stimulates formation of oxytocin receptors in uterine smooth muscle
- enhances vascularizaion (placental blood vessel creation and nutrient exchange with fetus)
P:
- inhibits uterine contraction
- uterine growth
- ligaments loosen (greater risk for sprains)
E+P
- nausea
- mammary gland development
- uterine growth – accomodate growing fetus and contract to expel fetus
- fetal development
Prolactin
- placental and maternal (anterior pituitary) sources
- estrogen has mild stimulatory effect on prolactin secretion
- During pregnancy, prolactin contributes to mammary gland growth and progesterone inhibits milk production
- Post partum, progesterone decreases, so milk can be released –> stimulated by sucking nipple which removes effect of dopamine (PIH)
human placental lactogen
- stimulates mammary gland development
- mobilization and metabolism of maternal fat stores (breaks down lipids and uses glucose for fetal growth)
in the mom
- decreases use of glucose
- insulin resistance = decreases uptake of glucose into maternal cells = gestational diabetes (3-10%) –> 1/2 develop type 2 diabetes
relaxin
- placentta (and corpus luteum)
- inhibits uterin contractions
- relaxes cartilate bt 2 pubis bones (pubic syphysis) – more easily widens pelvis during birth
- cervical effacement = stretches and gets thinner
Relaxin from corpus luteum increases post ovulation and prepares endometrium and inhibits uterine contraction
endorphins
Placental growth hormone
Corticotropin releasing hormone
Vitamin D3
- natural pain killers (opium)
- enhances nutrient availability to fetus: stimulates lipid breakdown (lipolysis) and glucose production (gluconeogenesis)
- (fetal and placental) increases cortisol to help mom deal with stress (more glucose in blood) –> also promotes fetal maturation of lungs (surfactant)
- increases calcium absorption
Urinary system changes
- similar effects to aldosterone: increases Na+ and water reabsorption –> edema during pregnancy and mentrual cycle
- kidneys produce more urine due to higher metabolic rate, blood volume, and waste production
- growing fetus puts pressure on bladder
cardiovacular system changes
- 40% increase in blood volume (higher CO and HR)
- Vasodilation (lower resistance and blood pressure) –> normalizes near end of pregnancy
- uterus presses on pelvic blood vessels –> compromises venous return from lower limbs leading to swollen feet/legs and varicose veins