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Pharmacology > Quiz > Flashcards

Quiz Flashcards

1
Q

The most common receptor motive targeted by opthalmic drugs

A

G-protein coupled

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2
Q

According to Fick’s Law of diffusion, whick of the following changes would contribute to greater level of flux

A

C1>C2

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3
Q

5ml of 2% drug A, 6ml of 3% drug B, 8ml of 8% drug C, 1ml of 6% drug D are combined in a solution. What is the resultant concentration of drug A?

A

0.5%

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4
Q

How many mg of tropicamide is in 25ul of 0.5% solution?

A

0.125mg

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5
Q

Which FDA drug schedule corresponds to moderate level of drug abuse potential

A

III

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6
Q

According to FDA, off label prescribing for a prescription includes deviations from the official monograph of all but which of the following examples

  • Dose
  • Dose frequency
  • Sudden drug discontinuation
  • Route of delivery
A

Sudden drug discontinuation

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7
Q

For a weakly acidic drug pKa 5.5, what ph would result in the majority of the drug being lipophylic?

  • 2.5
  • 4.5
  • 6.5
  • 8.5
A

8.5

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8
Q

Generic topical opthalmic drugs can vary from one another in which of the following ways

  • Bioavailability
  • Acrive ingredient
  • Stability
  • Purity
A

Bioavailability

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9
Q

How would you classify the use of thyroid hormone by an adult with thyroid disease

  • Therapeutic
  • Symptomatic
  • Prophylactic
  • Supplemental
A

Supplemental

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10
Q

How many mg of ephedrine are in a 20ul drop of 1:20000 preparation

A

0.001

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11
Q

Your px complains of a headache after taking a standard dose of 200mg of a drug twice a day. What modification would be the most appropriate

  • 400mg once daily
  • 100mg four times daily
  • 100mg twice a day
  • 200mg once daily
A

100mg four times daily

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12
Q

Which of the following agonist subtypes acts on receptors with constitutive activity

  • Inverse
  • Indirect
  • Partial
  • Direct
A

Inverse

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13
Q

Which isoform of cytochrome P450 enzymes is touted as being responsible for the metabolism of over 50% of prescription drugs

  • 2C9
  • 2D6
  • 2C8
  • 3A4
A

3A4

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14
Q

A drug has a bioavailability of 0.8 in elixer form and 0.4 in tablet form. If normal dosing of the tablet form is a total of 400mg per day, which dose regimen would be equivalent in the elixer

  • 100mg 3xper day
  • 50mg 2xper day
  • 50mg 4xper day
  • 100mg 4x per day
A

50mg 4xper day

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15
Q

What time interval does it take for most orally administered drugs to reach peak plasma concentration?

  • 1-2hours
  • 30-60min
  • 10-20min
  • 2-4 hours
A

1-2 hours

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16
Q

Tachyphylaxis is defined as

  • Rapidly reduced drug response
  • Initially reduced drug response
  • Serious adverse reaction to drug
  • Highly positive drug response
A

Rapidly reduced drug response

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17
Q

Spare receptor theory refers to:

  • Initial failure of a reversable antagonist to diminish a response
  • Initial failure of an irreversible antagonist to diminish a response
  • An unlimited number of receptors available to produce a response
  • Initial potential of an agonist to produce an exaggerated response
A

Initial failure of an irreversible antagonist to diminish a response

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18
Q

Schild equation illustrates how a

  • Decline in C’ when Ki is reduced
    -Decline in C when Ki is reduced
  • Rise in C when Ki is reduced
    Rise in C’ when Ki is reduced
A

Rise in C’ when Ki is reduced

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19
Q

Unlike enterohepatic circulation, hepatic portal circulation is involved in processing

  • lipophylic drugs
  • bilirubin
  • nutrients
  • biliary acids
A

Nutrients

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20
Q

Which body compartment contains the most fluid volume

  • Interstitial
  • Fat tissues
  • Blood
  • Intracellular
A

Intracellular

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21
Q

Which drug can cause diplopia

A
  • Lisinopril
  • Amlodipine
  • Escitalopram
  • Alprazolam
22
Q

Which % of Americans have hypertension

A

15%

23
Q

Which statement abour the renin-angiotensin-aldosterone system is true

  1. Renin results in a rise in angiotensin levels
  2. ACE results in a rise in bradykinin
  3. ACE results in rise in angiotensin I
  4. Angiotensin II leads to rise in aldosterone
A

4.

  • ACE inhibitors cause increase in bradykinin
  • ACE results in angiotensin 1 conversion into angiotensin 2
  • Renin results in angiotensinogen conversion into angiotensin 1
24
Q

Which drug is centrally acting

  1. Guanfacine
  2. Lisinopril
  3. Amlodipine
  4. Losartan
A
  1. Guanfacine - (Central alpha-2 Adrenergic Agonist)
  • Lisinopril - (ACE inhibitor)
  • Amlodipine - (Calcium channel blocker)
  • Losartan - (Angiotensin 2 Receptor Blocker)
25
Q

Which condition involves changes in GABA tone

A

Anxiety

26
Q

What drugs can cause floppy iris syndrome?

A
  • Tamsulosin
  • Terazosin
27
Q

Which of the following is an anticholinergic effect

  1. Sedation
  2. Sweating
  3. Diarrhea
  4. Hypotension
A

Sedation

28
Q

Botox acts by:

  1. Blocking M receptor
  2. Blocking N receptor
  3. Blocking ACh synthesis
  4. Blocking ACh release
A

Blocking ACh release

29
Q

An increase in parasympathetic tone produces all of the following responses except

  1. Bradycardia
  2. Vasodilation
  3. Diaphoresis(cold sweats)
  4. Reduced gastric pH
A

Diaphoresis

30
Q

Which receptor has a role in the inhibitory feedback within the ANS

  1. Alpha 1
  2. Alpha 2
  3. Beta 1
  4. Beta 2
A

Alpha 2

31
Q

Which effect is consistent with fight/flight

  1. Glycogen breakdown
  2. Bronchoconstriction
  3. Bradycardia
  4. Platelet inhibition
A

Glycogen breakdown

32
Q

Which condition nvolves changes in GABA tone?

  1. Mania/psychosis
  2. ADHD
  3. Anxiety
  4. Depression
A

Anxiety

33
Q

Widespread supression of sympathetic tone is the therapeutic approach used to treat:

  1. Mania/psychosis
  2. ADHD
  3. Anxiety
  4. Depression
A

Anxiety

34
Q

Cataracts are a recognised side effect of a drug/drugs used to treat:

  1. Mania/psychosis
  2. ADHD
  3. Anxiety
  4. Depression
A

Mania/psychosis

35
Q

Which class of antidepressants are considered out-dated due to its poo receptor selectivity

  1. MAOI
  2. TCAD
  3. SNRI
  4. SSRI
A

TCAD

36
Q

Ptosis is side effect of a drug used to treat:

  1. Mania/psychosis
  2. ADHA
  3. Anxiety
  4. Depression
A

Depression (Escitalopram)

37
Q

Which drugs can cause angioedema

A
  • Lisinopril (ACE inhibitor)
  • Losartan (Angiotensin receptor blocker)
  • Clonidine (Alpha agonist)
  • Alprazolam (Benzo-anxiety)
38
Q

Which drugs can cause conjunctivitis?

A
  • Amlodipine(Calcium channel clocker)
  • Escitalopram (SSRI)
39
Q

Which drugs can cause retinal hemorrhage?

A
  • Lisinopril
  • Sildenafil
40
Q

Which drug can cause cyanopsia(blue vision)

A

Sildenafil

41
Q

Which drug can cause corneal deposits?

A

Amiodarone with > 6month use

42
Q

Which drug can cause optic neuritis

A

Amiodarone

43
Q

Which drug can cause optic neuropathy

A

Amiodarone

44
Q

Which drug can cause ptosis(drooping eyelid)

A

Escitalopram

45
Q

Which drugs can cause cataracts

A

Quetiapine

Haloperidol

Chlorpromazine

46
Q

Which drug can cause ocular pigmentation

A

Chlorpromazine

47
Q

Which drug can cause night blindness?

A

Chlorpromazine

48
Q

Which drug can cause salt & peper fundus?

A

Chlorpromazine

49
Q

Which drug can cause nystagmus?

A

Phenytoin

50
Q

Which drug can cause retinopathy?

A

Haloperidol

Chlorpromazine

Pharmacology (19 decks)

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