Quiz Flashcards
The most common receptor motive targeted by opthalmic drugs
G-protein coupled
According to Fick’s Law of diffusion, whick of the following changes would contribute to greater level of flux
C1>C2
5ml of 2% drug A, 6ml of 3% drug B, 8ml of 8% drug C, 1ml of 6% drug D are combined in a solution. What is the resultant concentration of drug A?
0.5%
How many mg of tropicamide is in 25ul of 0.5% solution?
0.125mg
Which FDA drug schedule corresponds to moderate level of drug abuse potential
III
According to FDA, off label prescribing for a prescription includes deviations from the official monograph of all but which of the following examples
- Dose
- Dose frequency
- Sudden drug discontinuation
- Route of delivery
Sudden drug discontinuation
For a weakly acidic drug pKa 5.5, what ph would result in the majority of the drug being lipophylic?
- 2.5
- 4.5
- 6.5
- 8.5
8.5
Generic topical opthalmic drugs can vary from one another in which of the following ways
- Bioavailability
- Acrive ingredient
- Stability
- Purity
Bioavailability
How would you classify the use of thyroid hormone by an adult with thyroid disease
- Therapeutic
- Symptomatic
- Prophylactic
- Supplemental
Supplemental
How many mg of ephedrine are in a 20ul drop of 1:20000 preparation
0.001
Your px complains of a headache after taking a standard dose of 200mg of a drug twice a day. What modification would be the most appropriate
- 400mg once daily
- 100mg four times daily
- 100mg twice a day
- 200mg once daily
100mg four times daily
Which of the following agonist subtypes acts on receptors with constitutive activity
- Inverse
- Indirect
- Partial
- Direct
Inverse
Which isoform of cytochrome P450 enzymes is touted as being responsible for the metabolism of over 50% of prescription drugs
- 2C9
- 2D6
- 2C8
- 3A4
3A4
A drug has a bioavailability of 0.8 in elixer form and 0.4 in tablet form. If normal dosing of the tablet form is a total of 400mg per day, which dose regimen would be equivalent in the elixer
- 100mg 3xper day
- 50mg 2xper day
- 50mg 4xper day
- 100mg 4x per day
50mg 4xper day
What time interval does it take for most orally administered drugs to reach peak plasma concentration?
- 1-2hours
- 30-60min
- 10-20min
- 2-4 hours
1-2 hours
Tachyphylaxis is defined as
- Rapidly reduced drug response
- Initially reduced drug response
- Serious adverse reaction to drug
- Highly positive drug response
Rapidly reduced drug response
Spare receptor theory refers to:
- Initial failure of a reversable antagonist to diminish a response
- Initial failure of an irreversible antagonist to diminish a response
- An unlimited number of receptors available to produce a response
- Initial potential of an agonist to produce an exaggerated response
Initial failure of an irreversible antagonist to diminish a response
Schild equation illustrates how a
- Decline in C’ when Ki is reduced
-Decline in C when Ki is reduced - Rise in C when Ki is reduced
Rise in C’ when Ki is reduced
Rise in C’ when Ki is reduced
Unlike enterohepatic circulation, hepatic portal circulation is involved in processing
- lipophylic drugs
- bilirubin
- nutrients
- biliary acids
Nutrients
Which body compartment contains the most fluid volume
- Interstitial
- Fat tissues
- Blood
- Intracellular
Intracellular
Which drug can cause diplopia
- Lisinopril
- Amlodipine
- Escitalopram
- Alprazolam
Which % of Americans have hypertension
15%
Which statement abour the renin-angiotensin-aldosterone system is true
- Renin results in a rise in angiotensin levels
- ACE results in a rise in bradykinin
- ACE results in rise in angiotensin I
- Angiotensin II leads to rise in aldosterone
4.
- ACE inhibitors cause increase in bradykinin
- ACE results in angiotensin 1 conversion into angiotensin 2
- Renin results in angiotensinogen conversion into angiotensin 1
Which drug is centrally acting
- Guanfacine
- Lisinopril
- Amlodipine
- Losartan
- Guanfacine - (Central alpha-2 Adrenergic Agonist)
- Lisinopril - (ACE inhibitor)
- Amlodipine - (Calcium channel blocker)
- Losartan - (Angiotensin 2 Receptor Blocker)
