BPH Flashcards

1
Q

Drug classes used in treatment of benign prostatic hypertrophy

A

Alpha Blockers

  • Reduces tension of prostatic smooth muscle

5-Alpha reductase inhibitors

  • Reduces size of prostate gland
  • Treatment of 6-12months usually needed to reduce size sufficiently
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2
Q

Examples of Alpha Blockers used in BPH

A
  • Terazosin
  • Tamsulosin
  • Doxazosin
  • Alfuzosin
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3
Q

Examples of 5-Alpha reductase inhibitors

A
  • Finasteride
  • Dutasteride
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4
Q

Can 5-Alpha reductase inhibitors and alpha blockers be given together to trea BPH?

A

Yes, greatest reduction in BPH symptoms such as acute urinary retention, urinary incontenence, renal insufficiency, recurrent bladder infections

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5
Q

Mechanism of action of Tamsulosin

A

Selective competitive antagonism of lower urinary tract
alpha-1 adrenergic receptors, relaxing smooth muscle of
the bladder neck and prostate resulting in improved urine
flow

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6
Q

Indications of Tamsulosin

A

(Alpha 1 antagonist)

  • BPH
  • Nephrolithiasis (kidney stones-relaxes urethra)
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7
Q

Adverse effects of Tamsulosin

A

(Alpha 1 blocker)

  • Sinusitis
  • Dizziness
  • Pharyngitis
  • Cough
  • Infection
  • Orthostatic hypotension
  • Syncope

Ocular

  • Intraoperative floppy iris syndrome
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8
Q

Cautions for use of Tamsulosin

A

(Alpha 1 antagonist)

  • Glaucoma surgery
  • Cataract surgery
  • Sulphonamide allergy
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9
Q

Mechanism of action of Finasteride

A

(5-alpha reductase inhibitors)(androgen)

Inhibits type II 5-alpha-reductase, interfering with conversion of
testosterone to 5-alpha-dihydrotestosterone

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10
Q

Indications of Finasteride

A
  • BPH
  • Male pattern baldness
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11
Q

Adverse reactions of Finasteride

A

(5-Alpha reductase inhibitors)

  • Orthostatic hypotension
  • Angioedema
  • Prostate cancer(increased testosterone)
  • Breast cancer(increased testosterone)
    *
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12
Q

Major side effects of 5-Alpha reductase inhibitors

A
  • Lower libido
  • Erectile/ejaculatory dysfuction
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13
Q
A
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