Quiz 1 Supp

Question 1

What is the creatinine clearance of a female that is 5’6”, 140 lbs, and 76 years old? Her creatinine = 1.1.

Answer 1

45. 5+ (2.36)= 59.3 IBW
    (59. 3) * (140-76) 0.85 = 3225.92/
    1. 1*72 = 79.2
    40. 73ml/min CrCl

Actual BW= 63.63

Question 2

Adjusted Body weight equation

Answer 2

0.4(ABW-IBW)+IBW=

Question 3

Example: female patient, height = 5’4” weight = 275 pounds

Answer 3

275/2.2=125 kg Actual Body Weight
45.5+ (2.34) = 54.7 IBW
ABW-IBW 125-54.7=70.3
0.4(70.3) + 54.7=82.82 ABW

Question 4

Ideal Body Weight equations.

Answer 4

45.5+ (2.3* inches >5ft)= Female

50 + (2.3* inches >5ft)= Male

Question 5

What is steady state?

Answer 5

Amount of drug administered over time = amount of drug eliminated during the same time period
rate in = rate out
After 5 Half lives of drug

Question 6

Does a loading dose shorten the time to steady state?

Answer 6

No - After 5 Half lives a steady state is reached. It can only get you to therapeutic concentrations faster

Question 7

What do troughs & Peaks check for?

Answer 7

Trough for efficacy

Peaks for toxicity

Question 8

What is tolerance?

Answer 8

Tolerance represents a decreased response to a drug

Metabolic-drug is metabolized more rapidly after chronic use.

Cellular –decreased number of receptors, “downregulation

Question 9

What is dependence?

Answer 9

Dependence occurs when a patient needs a drug to “function normally”. Physical or psychological dependence.