Quiz 1 drugs (ANS) Flashcards
What is the effect of NE on heart rate, blood pressure and PR?
*Note mostly used in OR
What is the effect of EPI on heart rate, blood pressure and PR?
*Note increasing the dose can cause an increase in blood pressure
What is the effect of Isoproterenol on heart rate, blood pressure and PR?
Which sympathomimetic drug has far higher affinity for alpha receptors than for beta?
Do dobutamine and isoproterenol have a preference for alpha or beta receptors?
Beta receptors
Does isoproterenol or dobutamine have a preference for beta-1 receptors?
Dobutamine has a preference for beta-1 receptors (isoproterenol binds beta 1 & 2 roughly equally)
Can dopamine activate beta and alpha receptors?
Yes, at higher doses
Which G protein is responsible for activating phospholipase C?
Which G protein is responsible for inhibiting adenylyl cyclase?
Which G protein is responsible for stimulating adenylyl cyclase?
How does the acronym “qiss” help with recall of which G protein/2nd messenger system is used with alpha or beta receptors?
a1a2b1b2 “q i s s”
alpha-1: Gq -> PLC -> IP3
alpha-2: Gi -> inhibit AC
Beta-1: Gs -> stimulate AC
Beta-2: “
What G protein/2nd messenger system is associated with M2 receptors? Which is associated with M3 receptors?
What 5 similes are used to describe the symptoms anticholingergic toxicity?
What acronym is used to describe the symptoms of cholinergic toxicity?
What is the MoA of Vasopressin? What is it indicated for?
What is the MoA of Norepinephrine? What is it indicated for? What is a notable side effect?
What is the MoA of Epinephrine? What is it indicated for?
What is the MoA of Phenylephrine? What is it indicated for? What is a notable side effect?
What is the MoA of Oxymetazoline? What is it indicated for?
What is the MoA of Midodrine? What is it indicated for?
What is the MoA of Clonidine? What is it indicated for?
What is the MoA of Methyldopa? What is it indicated for?
What is the MoA of Guanfacine? What is it indicated for?
What is the MoA of Dexmedetomidine? What is it indicated for? What is a notable side effect?
What is the MoA of Brimonidine? What is it indicated for?
What is the MoA of Apraclonidine? What is it indicated for?
What is the MoA of Dobutamine? What is it indicated for?
What is the MoA of Isoproterenol? What is it indicated for?
What is the MoA of Terbutaline? What is it indicated for?
What is the MoA of Albuterol/levalbuterol? What is it indicated for?
What is the MoA of Salmeterol? What is it indicated for?
What is the MoA of Formoterol? What is it indicated for?
What is the MoA of Mirabegron? What is it indicated for?
What is the MoA of Dopamine? What is it indicated for?
What is the MoA of Fenoldopam? What is it indicated for?