Quiz 1 Flashcards

1
Q

Immunology began as a branch of

A

Microbiology

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2
Q

Immunology grew out of the study of _____& the _____ response to them

A

infectious diseases

body’s

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3
Q

Immune System is the body’s defense system against invasion by ______

A

microbes

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4
Q

Immunity is originated from Latin word ____

A

IMMUNIS

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5
Q

The word immunology first appeared in the ________ in _______

A

Index Medicine 1910

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6
Q

Immune system is the body’s defense system against _____ microbes

A

pathogenic

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7
Q

Immune system is made up of ____ that are distributed throughout the body, & predominantly in the

A

cells

lymphoreticular organs

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8
Q

Immune system function is to (3)

A
  1. Recognize
  2. Respond
  3. Eliminate foreign invaders
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9
Q

A historian from the ____ era, (Ancient Greece) pointed out about 2500 years ago, in a remarkable description of an epidemic in ____ (of what might have been typhus fever or plague), that those people who recovered from the disease were never attacked by it a second time. What was his name, ____

A

Peloponnesian
Athens
Thucydides

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10
Q

Attempts in ___ & ___ to induce immunity by inoculating well persons with materials scraped from skin lesion (pustules) of persons suffering from small pox. The procedure was called ____ & was hazardous. This took place in the ____ era

A

China
Turkey
variolation
Middle Ages = awareness

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11
Q

A practice brought to England by ____ for its positive effects, but later outlawed because of hazardous effects; what was it called ____.

A

Lady Mary Wortley Montagu

Variolation

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12
Q

In the late 18th century, a safe related procedure was established by ____. He, a country doctor in England, noted in 1798 that a pustular disease of the horse called ____ was frequently carried by farm workers to the nipples of cows, where it was picked up by ____ . Spots then began to appear on the hands of the domestics employed in milking. But what rendered the cow pox virus so extremely singular, was that the person who had been thus affected was forever after secure from the infection of small pox.

A

Sir Edward Jenner
“the grease”
milkmaids

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13
Q

Since ____ was unclear about the nature of the infectious agent of cow pox & its relation to small pox he inserted matter taken from a sore on _____ into the arm of an 8 year old boy by means of two superficial incisions. Two months later, Jenner inoculated the same boy with matter from a small pox patient. The boy’s exposure to the mild disease Cow Pox had made him immune to the deadly disease of small pox.
It is remarkable that Jenner’s work was not extended until nearly 100 years later by ____ that exploited the general principles underlying vaccination

A

Jenner
dairymaid
Pasteur

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14
Q

Louis Pasteur discovered, disproved & developed 3 important things:

  1. Fermentation was due to a _____ (1864)
  2. Disproved the theory of ________ (1867)
  3. Developed 3 attenuated ___ (1880):
A
  1. living microorganism (1864)
  2. spontaneous generation (1867)
  3. vaccines (1880):
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15
Q

The 3 attenuated vaccines developed by Louis Pateur

A
  1. Cholera vaccine
  2. Anthrax vaccine
  3. Rabies vaccine
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16
Q

Who was the Cholera vaccine for

A

chickens

17
Q

Who was the Anthrax vaccine for

A

sheep

18
Q

Who was the Rabies vaccine for

A

humans

19
Q

____ was first transmitted from in vitro culture to an ____ fulfilling ____ postulates, which were required to prove that the bacteria caused the disease (1876)

A

Anthrax
animal
Robert Koch

20
Q

In 1883, _____ observed the phagocytosis of fungal spores by leukocytes (phagocyte) & advanced the idea that immunity was primarily due to white blood cells. He won the ____ for his work on ____ in 1908

A

Elie Metchinkoff
Nobel Prize
Cellular Immunity

21
Q

In 1888, ____ showed that induction to infectious disease does not always require inoculation of ____. Following the demonstration of a powerful toxin in culture filtrate of ____ he showed that a non lethal dose of bacteria-free filtrates could induce Immunity to ____
Within 10 years most of the now known serological reactions were discovered

A

Von Behring
causative agent
diphtheria bacilli
diphtheria (Humoral Immunity)

22
Q

Name the 4 Humoral Immunity/Non- cellular part of blood (serum)

A
  1. Neutralization (toxin)
  2. Bacteriolysis (bacteria)
  3. Precipitation (toxin)
  4. Agglutination (bacteria)
23
Q

Name the 3 Cellular Immunity/Cellular part of blood

A
  1. White blood cells (phagocyte) engulf bacteria
  2. Phagocytosis is more efficient in immunized animal
  3. Cells also are important in Immunity
24
Q

Later works showed that all the above are the result of

A

Antibody = Humors

25
Q

Discovered antibody in plasma cells

A

Astrid Fagraeus

26
Q

3 Theories in Immunology

A
  1. Side Chain Theory
  2. Natural Selective Theory
  3. Cell selection & Clonal selection Theory
27
Q

______ proposed the side chain theory in 1900. According to ______, cells possessed on their surfaces a wide variety of side chains (now we call them antigen receptors) that were used to bring nutrients into the cells. When toxic substances blocked one of these side chains through an accidental affinity, the cell responded by making a large number of that particular side chain, some of which spill out into the blood & function as circulating antibodies.

A

Paul Ehrlich

28
Q

In 1955 ____ proposed his natural selection theory of antibody formation, in which randomly diversified antibody molecules were thought to _____ after ____ to injected antigen

A

Niels Jerne
replicate
binding

29
Q

In 1957 two new theories of antibody production were proposed by ____ & ____
Both theories substituted the natural selective theory, & proposed that the interaction of antigens with receptors on the cell surface stimulated ______& _____ of selected cells. After more than 30 years, the cell selection theory & the name given to it by Burnet (Clonal Selection), have become part of the established dogma of immunology. This theory has been confirmed by numerous experiments later & is current theory.

A

Talmage & Burnet

antibody formation & replication

30
Q

Our Host Defenses can be divided into 2 categories

A
  1. Innate (natural)

2. Acquired (adaptive)