Exam 1 questions Flashcards
Antibodies are produced by
Plasma Cells
Acquired Immunity
Specific
Mucous membranes
Physical Barrier
Body Temperature
Physiological Barrier
Cytokine/lymphokine
T-Cells
Which scientist is considered to be the founder of cell mediated immunity
Elie Metchnikoff
Which scientist is considered to be the founder of humoral immunity?
Emil von Behring
Bronchus-associated lymphoid tissue is important part of primary organs/tissue of immune system
False
Lymph node does NOT account for which of the following functions?
a) Draining interstitial fluid
b) Transporting dietary lipids
c) Draining blood
d) Protecting against infection
b) Transporting dietary lipids
Which of the following parts of the spleen account for activation of immune competent cells?
a) Red pulp
b) Coritcal pulp
c) Medullary pulp
d) White pulp
d) White pulp - B & T Lymphocytes
Red pulp - containing macrophages & RBC’s
Coritcal pulp - Part of lymph nodes
Medullary pulp - Part of lymph nodes
Which of the following theories of antibody synthesis was established by professor Burnet?
a) Clonal selection theory
b) Selective Theory
c) Side Chain Theory
d) None of the above.
a) Clonal selection theory
Selective Theory - Niels Jerne Side Chain Theory - Paul Erhlich
Which of the following cells are NOT considered phagocytic ones?
a) Eosinophils
b) Monocytes
c) Basophils
d) Neutrophils
c) Basophils
Eosinophils - Fights Parasitic Infection
Monocytes - Most important
Neutrophils - Are the most common in the circulation
Which of the following is the correct name of thymus cells accounting for secretion of thymic hormones?
a) Germinal Cells
b) Nurse cells
c) Medullary cells
d) Cortical cells
b) Nurse cells
Blood concentration of which of the following white blood cells is increased in the presence of bacterial infection in the body?
a) Mast cells
b) Neutrophils
c) Basophils
d) Eosinophils
b) Neutrophils
Vasodilation in inflammation process causes
a) Increase in blood vessel diameter
b) Local increase in number of erythrocytes
c) Increase in velocity of blood flow
d) All of the above
d) All of the above
Microglial cells in brain represent which of the following cells?
a) Lymphocyte
b) Basophils
c) Eosinophils
d) Macrophages
d) Macrophages
Kupler - liver
Mesangial - kidneys
Langerhan - skin.
Which of the following scientists and physicians developed variolation in a safe manner?
a) Louis Pasteur
b) Edward Jenner
c) Paul Ehrlich
d) Emil von Behring
b) Edward Jenner
Louis Pasteur - Vaccines
Examples of chemical barrier to infection is/are
a) Body temperature
b) Cilia
c) Oil on Skin
d) B and C
c) Oil on Skin
Body temperature - Physiological
Cilia - Mechanical
Non-specific host defense is associated with
a) Feces
b) Blood
c) Pus
d) Tears
d) Tears
Exogenous source of pyrogen for fever is
a) Production of antibody by B-cells
b) Production of histamine by mast-cells
c) Production of interleukin by macrophage
d) Lipopolysaccharide of gram negative bacteria
d) Lipopolysaccharide of gram negative bacteria (Endotoxin)
Marginal zone of _____ contains marginal zone B-cells and macrophages. These B-cells are responsible to respond to T-cell independent antigen such as polysaccharide.
a) Thymus
b) Bone Marrow
c) Spleen
d) Lymph Node
c) Spleen
Thymus -The Subcapsular zone:
Contain the earliest progenitor cells & epithelial cells
Polymavirus (DNA Virus) causes tumor in “nude mice” (nude mice do not have mechanism to generate mature T-Lymphocytes, genetic defect) but not in normal mice. Best Interpretation is that
a) Macrophages are required to reject polymavirus induced tumors
b) Natural Killer cells can reject polymavirus induced tumors without help from T-Cells.
c) T-cells play important role in rejection of polymavirus induced tumors.
d) B-Cells play no role in rejection of polymavirus induced tumors
???
Your patient is a child who has no detectable T-Cells or B-Cells. This immunodeficiency will most probably result in defect of
a) Stem cells originating in bone marrow
b) T-Cell/B-Cell interaction
c) Thymus
d) Bursa of Fabricus
a) Stem cells originating in bone marrow
Localized and primary sign of inflammation is
a) Calor
b) Tumor
c) Fever
d) All of the above
e) A and B
e) A and B
Fever - Systemic
Which one of these is a major cytokine producer
a) B-cells
b) Cytotoxic T-Cells
c) T-helper cells
d) T-suppressor cells
c) T-helper cells
B-cells
Cytotoxic T-Cells - death on target T-cells
T-suppressor cells/AKA Regulatory T cell - cells can suppress the immune response to specific antigen
Which of the following is a major function of the lymphoid system?
a) Innate immunity
b) Inflammation
c) Phagocytosis
d) Acquired Immunity
???
Which subset of WBC’s account for acquired, specific immunity?
a) Monocytes
b) B-Cells
c) T-Cells
d) B and C
d) B and C
Morphologically and functionally similar to basophils, what cells are bound to connective tissue?
a) Neutrophils
b) Eosinophils
c) Mast Cells
d) Monocytes
e) Lymphocytes
c) Mast Cells
Phagocytes that respond early in inflammatory response to bacteria are
a) Macrophages
b) Eosinophils
c) Neutrophils
d) Lymphocytes
e) None of the above
c) Neutrophils
These leucocytes have no identifiable membrane markers, can fight against cancer and belong to innate immunity
natural killer cells
The maturation of T cells will be done in ____________
thymus
A cytokine that stimulate the activation of B cells and T cells is
interleukin-2
