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Micro3 > Exam 1 questions > Flashcards

Exam 1 questions Flashcards

1
Q

Antibodies are produced by

A

Plasma Cells

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2
Q

Acquired Immunity

A

Specific

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3
Q

Mucous membranes

A

Physical Barrier

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4
Q

Body Temperature

A

Physiological Barrier

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5
Q

Cytokine/lymphokine

A

T-Cells

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6
Q

Which scientist is considered to be the founder of cell mediated immunity

A

Elie Metchnikoff

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7
Q

Which scientist is considered to be the founder of humoral immunity?

A

Emil von Behring

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8
Q

Bronchus-associated lymphoid tissue is important part of primary organs/tissue of immune system

A

False

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9
Q

Lymph node does NOT account for which of the following functions?

a) Draining interstitial fluid
b) Transporting dietary lipids
c) Draining blood
d) Protecting against infection

A

b) Transporting dietary lipids

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10
Q

Which of the following parts of the spleen account for activation of immune competent cells?

a) Red pulp
b) Coritcal pulp
c) Medullary pulp
d) White pulp

A

d) White pulp - B & T Lymphocytes

Red pulp - containing macrophages & RBC’s
Coritcal pulp - Part of lymph nodes
Medullary pulp - Part of lymph nodes

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11
Q

Which of the following theories of antibody synthesis was established by professor Burnet?

a) Clonal selection theory
b) Selective Theory
c) Side Chain Theory
d) None of the above.

A

a) Clonal selection theory

Selective Theory - Niels Jerne Side Chain Theory - Paul Erhlich

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12
Q

Which of the following cells are NOT considered phagocytic ones?

a) Eosinophils
b) Monocytes
c) Basophils
d) Neutrophils

A

c) Basophils

Eosinophils - Fights Parasitic Infection
Monocytes - Most important
Neutrophils - Are the most common in the circulation

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13
Q

Which of the following is the correct name of thymus cells accounting for secretion of thymic hormones?

a) Germinal Cells
b) Nurse cells
c) Medullary cells
d) Cortical cells

A

b) Nurse cells

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14
Q

Blood concentration of which of the following white blood cells is increased in the presence of bacterial infection in the body?

a) Mast cells
b) Neutrophils
c) Basophils
d) Eosinophils

A

b) Neutrophils

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15
Q

Vasodilation in inflammation process causes

a) Increase in blood vessel diameter
b) Local increase in number of erythrocytes
c) Increase in velocity of blood flow
d) All of the above

A

d) All of the above

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16
Q

Microglial cells in brain represent which of the following cells?

a) Lymphocyte
b) Basophils
c) Eosinophils
d) Macrophages

A

d) Macrophages

Kupler - liver
Mesangial - kidneys
Langerhan - skin.

17
Q

Which of the following scientists and physicians developed variolation in a safe manner?

a) Louis Pasteur
b) Edward Jenner
c) Paul Ehrlich
d) Emil von Behring

A

b) Edward Jenner

Louis Pasteur - Vaccines

18
Q

Examples of chemical barrier to infection is/are

a) Body temperature
b) Cilia
c) Oil on Skin
d) B and C

A

c) Oil on Skin

Body temperature - Physiological
Cilia - Mechanical

19
Q

Non-specific host defense is associated with

a) Feces
b) Blood
c) Pus
d) Tears

A

d) Tears

20
Q

Exogenous source of pyrogen for fever is

a) Production of antibody by B-cells
b) Production of histamine by mast-cells
c) Production of interleukin by macrophage
d) Lipopolysaccharide of gram negative bacteria

A

d) Lipopolysaccharide of gram negative bacteria (Endotoxin)

21
Q

Marginal zone of _____ contains marginal zone B-cells and macrophages. These B-cells are responsible to respond to T-cell independent antigen such as polysaccharide.

a) Thymus
b) Bone Marrow
c) Spleen
d) Lymph Node

A

c) Spleen

Thymus -The Subcapsular zone:
Contain the earliest progenitor cells & epithelial cells

22
Q

Polymavirus (DNA Virus) causes tumor in “nude mice” (nude mice do not have mechanism to generate mature T-Lymphocytes, genetic defect) but not in normal mice. Best Interpretation is that

a) Macrophages are required to reject polymavirus induced tumors
b) Natural Killer cells can reject polymavirus induced tumors without help from T-Cells.
c) T-cells play important role in rejection of polymavirus induced tumors.
d) B-Cells play no role in rejection of polymavirus induced tumors

A

???

23
Q

Your patient is a child who has no detectable T-Cells or B-Cells. This immunodeficiency will most probably result in defect of

a) Stem cells originating in bone marrow
b) T-Cell/B-Cell interaction
c) Thymus
d) Bursa of Fabricus

A

a) Stem cells originating in bone marrow

24
Q

Localized and primary sign of inflammation is

a) Calor
b) Tumor
c) Fever
d) All of the above
e) A and B

A

e) A and B

Fever - Systemic

25
Q

Which one of these is a major cytokine producer

a) B-cells
b) Cytotoxic T-Cells
c) T-helper cells
d) T-suppressor cells

A

c) T-helper cells

B-cells
Cytotoxic T-Cells - death on target T-cells
T-suppressor cells/AKA Regulatory T cell - cells can suppress the immune response to specific antigen

26
Q

Which of the following is a major function of the lymphoid system?

a) Innate immunity
b) Inflammation
c) Phagocytosis
d) Acquired Immunity

A

???

27
Q

Which subset of WBC’s account for acquired, specific immunity?

a) Monocytes
b) B-Cells
c) T-Cells
d) B and C

A

d) B and C

28
Q

Morphologically and functionally similar to basophils, what cells are bound to connective tissue?

a) Neutrophils
b) Eosinophils
c) Mast Cells
d) Monocytes
e) Lymphocytes

A

c) Mast Cells

29
Q

Phagocytes that respond early in inflammatory response to bacteria are

a) Macrophages
b) Eosinophils
c) Neutrophils
d) Lymphocytes
e) None of the above

A

c) Neutrophils

30
Q

These leucocytes have no identifiable membrane markers, can fight against cancer and belong to innate immunity

A

natural killer cells

31
Q

The maturation of T cells will be done in ____________

A

thymus

32
Q

A cytokine that stimulate the activation of B cells and T cells is

A

interleukin-2

Micro3 (2 decks)

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