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Heme-Lymph > Quiz 1 > Flashcards

Quiz 1 Flashcards

1
Q

Soccer Ball Chromatin

A

CLL

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2
Q

infection
Necrosis
Drugs

A

Neutophilia

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3
Q

Chemotherapy
Immune destruction
Septic Shock

A

Neutopenia

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4
Q

Type 1 hypersensitivity
Parasites
HYPOcortisolism

A

Eosinophilia

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5
Q

Hypercellular BM with effective hematopoiesis

A

Myeloproliferative neoplasms

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6
Q

BCR-ABL fusion

increase tyrosine kinase

A

CML

Chronic Myelogenous Leukemia

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7
Q

JAK2 gene mutation in 100% of patients

A

PV

Polycythemia Vera

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8
Q

Teardrop cells

A

PMF

Primary myelofibrosis

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9
Q

proliferation of megakaryocytes

A

ET

Essential thrombocytopenia

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10
Q

t(9;22)

A

Philadelphia chromosome

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11
Q

t(9:22)

Philadelphia chromosome

A

CML

and B-Cell ALL (bad)

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12
Q

Decresed EPO

Increased RBC mass

A

PV

Polycythemia Vera

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13
Q

Atypical megakaryocytes

A

PMF

primary myelofibrosis

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14
Q

Atypical platelet morphology

A

ET

Essential thrombocytopenia

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15
Q

Basophilia associated MPN

A

CML

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16
Q

MPN treated with phlebotomy

A

PV

Polycythemia Vera

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17
Q

Treated with Alkylating agents

A

ET
Essential Thrombocytopenia
(It lowers platelet counts)

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18
Q

MPN treated with Gleevec (imatinib)

A

CML

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19
Q

JAK2 in ~50%

A

PMF and ET

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20
Q

Monosomy 7

A

MDS

Myelodysplastic syndrome

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21
Q

treat with hypomethylating agents

A

MDS myelodysplastic sydrome

want to increase transcription due to lost chromosome

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22
Q

t(8;21)
inv(16)
t(15;17)

A

Favorable AML

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23
Q

Auer Rods

A

AML

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24
Q

t(15;17)

treatment

A

Treat with ATRA (all-trans retinoic acid)

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25
Q

t(15;17) disease

A

Acute Promyelocytic leukemia

subset of AML

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26
Q

male child with >20% blasts

A

ALL

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27
Q

AML markers

A

CD34

CD117 (c-kit)

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28
Q

Treatment for MDS

A

Supportive
Hypomethylating agents
Allogenic Stem cell transfer

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29
Q

MPO and NSE stain

A

AML (for blasts)

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30
Q

Adults with >20% blasts

A

AML

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31
Q

Polyclonal expansion of lymphocytes

A

Reactive lymphocytosis

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32
Q

Monoclonal expansion of lymphocytes

A

Neoplastic Lymphocytosis

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33
Q 
CD34(+)
TdT(+)
CD10(+)
CD19(+)
CD20(-)
A

B-Cell ALL

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34
Q

young male with Thymic/mediastinal mass

A

T-cell ALL

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35
Q

Good prognosis for B-Cell ALL

A

HYPERploidy (>50)

t(12;21)

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36
Q

Bad prognosis for B-cell ALL

A

HYPOpoloidy

Philadelphia chomosome t(9;22)

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37
Q

T-Cell ALL markers

A

CD3
CD4
CD8
TdT

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38
Q

B cell and T cell pathogenisis

A

Aggressive

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39
Q

CD5(+) and CD23(+)

A

CLL

Chronic Lymphocytic Leukemia

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40
Q

Hairy projections

A

Hairy cell Leukemia

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41
Q

B-Cell ALL demographic

A

Children

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42
Q

Mature B-cell Neoplasms

A

CLL and Hairy cell

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43
Q

CD11c(+)
CD22(+)
CD19(+)
CD20(+)

A

Hairy cell

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44
Q

Flower cells

A

Adult T-cell leukemia

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45
Q

Cerebriform nuclei

A

Mycosis fungoides/Sezary Syndrome

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46
Q

Mature B-cell Neoplasm pathogenisis

A

Indolent

CLL and Hairy cell

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47
Q

HTLV-1 Provirus

Endemic region

A

Japan, West Africa, Carribean

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48
Q

HTLV-1 disease

A

Adult T-cell

flower cells

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49
Q

CD4(+)
CD25(+)
skin lesions
hypercalcemia

A

Adult-T cell

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50
Q

Demographic for Mature T-cell Neoplasms

A

Adults

Adult T-cell, Large Granular, Mycosis fungoides

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51
Q

Pathogenisis Adult T-cell Leukemia

A

Agressive

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52
Q

Pathogenisis T cell Large Granular Lymphocytic Leukemia

A

Indolent

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53
Q

T helper cells leukemia

A

Adult T cell

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54
Q

Cytotoxic T cell leukemia

A

Large Granular lymphocytic leukemia (CD8)

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55
Q 
CRAB
hyperCalcemia
Renal insufficiency
Anemia
Bone disease
A

Multiple myeloma

plasma cell neoplasm

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56
Q

Demographic for Multiple myeloma

A

AA retired men

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57
Q

Benign plasma cell proliferation

A

MGUS(monoclonal gammopathy of undetermined significance)

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58
Q

Bence Jones

A

In urine of Multiple Myeloma

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59
Q

Clonal plasma cells
M-Protein
End organ damage

A

Multiple myeloma

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60
Q

Congo Red

A

Amyloidosis

61
Q

BCL-2IgH fusion

A

Follicular Lymphoma

62
Q

t(11;14)

A

Mantle cell lymphoma

63
Q

t(14;18)

A

Follicular lymphoma

64
Q

EBV associated lymphadenopathy

A

Burkitt Lymphoma

65
Q

MALT1-IAP2 Fusion

A

MALToma

Extranodal marginal zone lymphoma

66
Q

Cyclin D1-IgH fusion

A

Mantle cell Lymphoma

67
Q

Retroperitoneal involement

A

Follicular lymphoma

68
Q

Diffuse lesions pathogenisis

A

Aggressive
Diffuse Large B cell
Burkitt lymphoma

69
Q

Associated with H.pylori and Hashimotos

A

MALToma

Extranodal marginal zone lymphoma

70
Q

Generalized lymphadenopathy

A

Follicular lymphoma

71
Q

Follicular can transform to_____

A

Diffuse large B cell is the majority

Burkitt lymphoma

72
Q

All mature B cell lymphomas are positive for ______

A

CD19

CD20

73
Q

CD5(-)

CD10(+)

A

Follicular

74
Q

CD5(+)
CD10(-)
CD23(-)

A

Mantle cell

75
Q

CD5(+)

CD23(+)

A

CLL

76
Q

CD5(-)

CD10(-)

A

MALToma

77
Q

c-Myc

A

Burkitt Lymphoma

78
Q

T(8;14)
t(2;8)
t(8;22)
A lot of 8s

A

Burkitt Lymphoma

79
Q

Burkitt lymphoma demographic

A

Adolescents

80
Q

Cytotoxic T cell Lymphoma

A

Anaplastic Large cell lymphoma

81
Q

Helper T cell lymphoma

A

Peripheral T cell lymphoma

82
Q

EBV assosiated mature T cell lymphoma

A

Extranodal NK/T cell lymphoma

83
Q

Pathogenisis of Mature T cell lymphomas

A

Aggressive

84
Q

Children with mature t-cell lymphoma

A

Anaplastic large cell lymphoma

85
Q 
ALK rearrangement
(tyrosine Kinase)
A

Anaplastic Large cell lymphoma

86
Q

sinonasal extra nodal destructive masses

A

Extranodal NK/T cell lymphoma

87
Q

Reed Sternberg Cells

A

Classical Hodgkin Lymphoma

88
Q

Mediastinum lymphoma

A

Classical Hodgkin

89
Q

Contiguous spread

A

Classical Hodgkin

90
Q

Axillary lymphoma

A

Nodular Hodgkin

NLPHL

91
Q

Young Hodgkin patient

A

Classical

92
Q 
CD15(+)
CD30(+)
multiple of 15
CD20(-) odd
CD45(-)
A

Classical

93
Q

CD20(+)
CD45(+)
CD15(-)
CD30(-)

A

NLPHL

Nodular Hodgkin

94
Q

Popcorn cells

A

NLPHL

Nodular Hodgkins

95
Q

T cell Markers

A

CD1a-8

Single digit

96
Q

B-cell markers

A

CD19-CD-22

97
Q

Generic Myeloid markers

A

CD13, CD15, CD33, CD117 (c-kit)

98
Q

Megakaryocyte markers

A

CD41

CD61

99
Q

Monocyte markers

A

CD14

100
Q

TdT

A

ALL

Immaturity marker

101
Q

CD34

A

Blast marker in AML and ALL

102
Q

CD117

A

AML blast marker

103
Q

CD1a

A

T-cell immaturity marker

104
Q

where does blood form before the 5th month

A

Yolk sac then liver

105
Q

CD15

A

Granulocytes

106
Q

CD45(-) myeloid lineage cells

A

Eythroid

Megakaryocyte

107
Q

EPO

A

Erythopoiesis

made in kidney

108
Q

Starry Sky

A

Burkitt Lymphoma

109
Q

Thrombopoietin

A

Stimulate megakaryocytes to produce platelets

110
Q

G-CSF

A

stimulate granulocytes (neutrophil)

111
Q

M-CSG

A

stimulate monocytes (macrophage)

112
Q

All royal blue large cell

A

Proerythroblast

113
Q

Large blue cell with a crescent of light blue cytoplasm

A

Myeloblast

114
Q

loss of nucleus

A

orthochromatic

Normoblast

115
Q

Small blue streaks in smaller red cell

A

Reticulocyte

116
Q

changing from blue to red

A

Polychromatic erythroblast

117
Q

kidney bean indentation

A

Metamyelocyte

118
Q

Amorphic nucleus

A

Band

119
Q

Primary granule formation

A

Promyelocyte

120
Q

Specific granule formation

A

myelocyte

121
Q

huge cell bigger than a blast

A

megakaryocyte

122
Q

whopping cough reaction

A

increase lymphocytes

123
Q

fungal/parasite reaction

A

Eosinophilia

124
Q

Appendicitis

A

Neutrophilia

125
Q

FLT3 in t(15;17)

A

AML
tryrosine kinase
Poor prognosis

126
Q

NPM1 in t(15;17)

A

AML
nucleocytoplasmic shuffling protein
Favorable prognosis

127
Q

Tennis racket

A

Langerhans cell Histocytic neoplasm

128
Q

Hand-Schuller-Christian triad

A

in Langerhans cell neoplasm
Bone Defect
Diabetes Insipidus
Exophthalmos

129
Q

Associated with Rheumatoid and high Ferritin levels

A

HLH

Hemophagocytic lymphohistocytosis

130
Q

3 regions of hypervariablility

A

CDR1,2,3

131
Q

Heavy chain components

A

D to J to V to C

132
Q

Light chain components

A

V to J to C

133
Q

Junctional diversity

A

removal or addition of nucleotides

134
Q

Allelic exclusion

A

maternal rearranges first
if successful. paternal is not expressed.
Only Maternal OR Paternal expressed

135
Q

positive selection

A

weak self

136
Q

Neg selection

A

strong self recognition

137
Q

death via neglect

A

no self recognition

138
Q

pancytopenia in mature B-cell leukemia

A

Hairy cell

139
Q

Rheumatoid
Eosinophilic granules
CD 8

A

T-cell Large granular Lymphocytic leukemia

140
Q

no plasma cells in bone marrow

80% upper respiratory

A

Plasmacytoma

141
Q

Waldenstrom macroglobulinemia

A

Lymphoblastic lymphoma
Visual impairment
Raynauds

142
Q

peripheral follicles

A

B-cells

143
Q

Paracortex in medulla

A

T cells and macrophage

144
Q

High endothelial venules

A

lymphocyte homing receptors

145
Q

Primary follicle

A

Naive B cell

146
Q

Secondary B follicle

A

lighter zone surrounded my dark mantle zone

B cells become activated

147
Q

tingible body macrophages

A

in germinal centers

stars in ‘starry sky’ of burkitt lymphoma

148
Q

Gout

Ruddy Face

A

PV

Heme-Lymph (3 decks)

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