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Antibiotics > Quinolones > Flashcards

Quinolones Flashcards

1
Q

Mode of action

A

Inhibit bacterial DNA gyrase (Topoisomerase II)

Prevents the DNA double-helix from supercoiling, preventing transcription and replication

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2
Q

Ciprofloxacin

A

Oral treatment for pseudomonas, gram negative cover for UTI, mutagen (C. diff outbreak)

Salmonella entiriditis (enterocolitis) and salmonella typhi/paratyphi (enteric fever)

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3
Q

Levofloxacin

A

Respiratory quinolone (strep pneumoniae and atypical pneumonia)

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4
Q

Adverse effects

A

GI upset, C. diff outbreak with ciprofloxacin, hypersensitivity, convulsions rarely, inhibit CYP450

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Antibiotics (7 decks)

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