Macrolides Flashcards
1
Q
Mode of action
A
- inhibit bacterial protein synthesis
- binds to 50s subunit of bacterial ribosome and prevent translocation of growing peptide chain
2
Q
Examples
A
Clarithromycin, Azithromycin, Erythromycin
3
Q
Common clinical usage
A
Alternative to penicillin, atypical pneumonia
4
Q
Clarithromycin
A
Campylobacter jejuni
5
Q
Erythromycin
A
Corynebacterium diphteriae, Strep pyogenes, Bordetella pertussis
6
Q
Adverse effects
A
GI upset, hypersensitivity, QT prolongation (Pro-arrhythmic), effects on cytochrome P450 system
7
Q
Azithromycin
A
Shigellosis
