QUINOLONAS Flashcards

1
Q

quinolonas de 1ra

A
  • ac. nalidixico
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2
Q

quinonolas de 2da

A
  • norfloxacino

- ciprofloxacino

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3
Q

quinonolas de 3ra

A
  • levofloxacino
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4
Q

quinonolas de 4ta

A
  • moxifloxacino
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5
Q

quinonolas de uso exclusivo para IVU bajas

A

quinonolas de 1ra

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6
Q

unica quinolona pura

A

quinonolas de 1ra

el resto son fluoroquinolonas

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7
Q

que cubre el ciprofloxacino

A
  • gram -
  • infecciones sistémicas
  • pseudomonas
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8
Q

que damos en otitis externa por pseudomonas

A

ciprofloxacino

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9
Q

que cubre levofloxacino (3ra)

A
  • gram (-) (+)
  • pseudomonas
  • intracelulares
  • microorganismos sin pared (mycoplasma)
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10
Q

quinonolas de 3ra tiene mejor cobertura para

A
  • gram + (strep)

- atípicos (mayoría neumonía)

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11
Q

que cubren las quinonolas de 4ta

A

lo mismo que 3ra + anaerobios

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12
Q

quinolonas muy usadas para infecciones de vías respiratorias

A

3ra y 4ta

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13
Q

mecanismo de acción de las quinonolas

A
  • acción en DNA girasa
    topoisomerasa II
    topoisomerasa IV
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14
Q

las quinolonas son sinérgicos con

A

beta lactámicos

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15
Q

antagónicos de quinonolas

A
  • cloranfenicol
  • rifampicina
  • nitrofurantoína
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16
Q

disminuyen la absorción de las quinonolas

A

antiácidos

17
Q

biodisponibilidad de

  • norfloxacino
  • ciprofloxacino
  • levofloxacin
  • moxifloxacino
A
  • norfloxacino 50-60%
  • ciprofloxacino 70%
  • levofloxacin >95%
  • moxifloxacino 90%
18
Q

cuando hay resistencia bacteriana del más del 20% a un fármaco:

A

ya no se debe usar como tx empírico