Quetiapine Fumerate (Antipsychotic)

Question 1

What is the brand name of Quetiapine FUmerate?

Answer 1

Seroquel

Question 2

What are the available tablet forms of Seroquel?

Answer 2

25 mg, 50 mg, 100 mg, 200 mg, 300 mg, 400 mg

Question 3

What strengths of extended release Seroquel tablets are available?

Answer 3

50 mg, 150 mg, 200 mg, 300 mg, 400 mg

Question 4

What are the FDA approved indications for Seroquel?

Answer 4

Schizophrenia, depressive episodes associated with bipolar disorder, acute manic episodes associated with bipolar one, major depressive order

Question 5

What is the main recommended dose for Seroquel?

Answer 5

Maintenance stuff should be between 300 and 400 mg daily, given 2 to 3 divided doses or one extended release tablet.

Question 6

What is the mechanism of action of quetiapine fumarate?

Answer 6

Quetiapine fumarate is a multiple neurotransmitter antagonist with activity at serotonin 5HT1A & 5HT2, dopamine D1 &D2, histamine H1, & adrenergic alpha-1 and alpha-2 receptors

Question 7

What are the drug interactions for Seroquel?

Answer 7

May have additive effective with other CNS depressants. Oral clearance is increased by phenytoin & thioridazine.

Question 8

What are the contraindications for quetiapine fumarate?

Answer 8

Far too many to type, review card.

Question 9

What are the adverse effects of Seroquel?

Answer 9

• Somnolence, dizziness, constipation, postural hypotension, try mouth, and dyspepsia
• Adverse affects occurring in approximately 1% of the patients include: hypertonia, flu central, anorexia, palpitations, laryngitis, rhinitis, cough, dyspnea, peripheral edema, swelling, leukopenia

Question 10

What should the pharmacist tell the patient when counseling them on the use of Seroquel?

Answer 10

• Use caution rising from a prone position, especially during initial dose-titration period.
• May cause drowsiness, use caution when performing activities that require alertness.
• May be taken without regard to meals.
• Seroquel XR should be swallowed whole and not crushed, divided, or chewed.
• Do not change dosage except on the orders of your physician.
• If a dose is missed, skip it and return to normal dosing schedule