Quantitative/Qualitative PLT Disorders

Question 1

What amount of PLTs will a patient have if we suspect them to bleed during surgery?

Answer 1

60 x 10^9/L

Question 2

What must be avoided to prevent Pre-analytical errors when conducting tests for Coagulation?

Answer 2

Blood:Anticoag - 9:1
At least 90% full
Properly mixed
No hemolysis
3.2% Sodium Citrate blue top

Question 3

What group does Hemolytic Uremic Syndrome (HUS) effect and what do we see in their peripheral smear?

Answer 3

Age 6 months - 4 years
PLT < 20,000
Schistocytes
Bloody Diarrhea

Question 4

What is the most prevalent inherited PLT adhesion disease/bleeding disorder?

Answer 4

Von Willebrand’s Disease

Question 5

What is responsible for drug related PLT abnormalities?

Answer 5

Aspirin (Most popular)
Inhibits production of TXA2

Question 6

What does excessive production of immunoglobulin and hyperviscosity/paraproteinemia cause?

Answer 6

Multiple Myeloma
Waldenstroms Macroglobulinemia

Question 7

What assesses vWF function by measuring binding of vWF to PLT GPIb?

Answer 7

Ristocetin Cofactor Assay