Fibrinogen, Thrombin, Fibrinolytic

Question 1

What is the principal substrate of the coagulation and fibrinolytic system?

Answer 1

Fibrinogen

Question 2

What are the functions of Fibrinogen?

Answer 2

Stabilize the blood clot
Be converted to fibrin

Question 3

What is the role of Thrombin?

Answer 3

Activation of the Platelet system
Activation of the Fibrinolytic System
Convert plasminogen to plasmin
Convert fibrinogen to fibrin

Question 4

After thrombin converts plasminogen to plasmin, what purpose does plasmin serve?

Answer 4

Digests fibrin and fibrinogen
Digests the clot

Question 5

What by products are created from the breakdown of Fibrin?

Answer 5

X, Y, D, E

Question 6

What by products are produced when Factor XIII is created?

Answer 6

D-Dimers

Question 7

What test do we use to measure degradation of cross linked fibrin?

Answer 7

D-dimer test

Question 8

What are the methods used for the D-dimer test?

Answer 8

Immune fluorescence
Immunoturbidity
Chemiluminescence
Semi-quantitively or Qualitatively

Question 9

What levels do we see of PT/APTT, Fibrinogen, and PLT in a DIC profile?

Answer 9

Increased PT/APTT
Decreased Fibrinogen
Decreased PLT