Qmax- Immu

Question 1

What in eosinophils that fight against protozoan infection

Answer 1

Major basic protein

Question 2

Meningitis of 0-6 month old kid

Answer 2

Group B Strep E. coli Listeria

Question 3

Wiskott-Aldrich syndrome

Answer 3

Abnormal cytoskeleton reorganization impairing cell signaling Present as: thrombocytopenia, recurrent infections with encapsulated organisms, eczema, and increased risk of autoimmune diseases

Question 4

Hyper IgE syndrome

Answer 4

STAT3 gene (AD) or DOCK8 gene (AR) Deficiency of Th17 Recurrent pneumonia caused by Staphylococcus aureus and Aspergillus fumigatus, deep organ abscesses, mucocutaneous candidiasis, hyperflexible joints, and recurrent fractures

Question 5

Celiac disease is associated with

Answer 5

IgA deficiency (Giardia), iron-deficiency anemia, autoimmune thyroid disease, type 1 diabetes, and dermatitis herpetiformis

Question 6

Type II hypersensitivity

Answer 6

Grave’s disease, Goodpasture

Question 7

Type III hypersensitivity

Answer 7

Poststreptococcal glomerulonephritis, Polyarteritis nodosa, Serum sickness

Question 8

Inactivated vaccines

Answer 8

RIP Always: Rabies, Influenza (injection), Polio (Salk), hepatitis A

Question 9

t(11;14) t(11;18) t(14;18) t(15;17)

Answer 9

t(11;14): Mantle cell lymphoma (cyclin D1 activation) t(11;18): Marginal zone lymphoma t(14;18): Follicular lymphoma (BCL-2 activation) t(15;17): APL (M3 of AML, Aeur rod!)

Question 10

HLA-B8 HLA-BW22 HLA-DR3 HLA-DR4

Answer 10

HLA-B8: Graves disease HLA-BW22: Kawasaki disease HLA-DR3: active autoimmune hepatitis, Sjögren, DM1 HLA-DR4: RA, DM1

Question 11

Ataxia Telangiectasia

Answer 11

a mutated ATM gene that results in defective DNA repair mechanisms (AR) -Low Ig A -Telangiectasias -Cerebellar degeneration: a staggering gait (ataxia), strabismus, oculomotor apraxia, nystagmus, difficulty with fine motor movements, dysarthria, chorea, athetosis, dystonia, and tremor.

Question 12

Adenosine deaminase deficiency: heritage?

Answer 12

AR

Question 13

Drug-induced immune hemolytic anemia

Answer 13

Penicillin acts as a hapten to cause RBC hemolysis. A hapten is a small molecule that cannot elicit an immune response on its own. It must form a complex with a large carrier, such as a protein, to be immunogenic.

Question 14

Poison ivy

Answer 14

Allergic contact dermatitis

Question 15

What type of immune response to parasites

Answer 15

Antibody-mediated destruction of parasites by eosinophils is referred to as antibody-dependent cell-mediated cytotoxicity

Question 16

What the cause of sarcoidosis granuloma

Answer 16

A cell-mediated immune response to an (unidentified) antigen

Question 17

Chédiak-Higashi syndrome

Answer 17

Wiskott-Aldrich + albinism

Question 18

IL-12 receptor deficiency

Answer 18

Decrease Th1 response, AR, Disseminated mycobacterial and fungal infections

Question 19

anti-CCP anti-Jo1 anti-Ro/SSA anti-La/SSB anti-Scl70 Anticentromere Antimitochondrial anti-endomysial anti-tissue transglutaminase deamidated gliadin peptide

Answer 19

RA Polymyositis, dermatomyositis Sjögren Sjögren Scleroderma CREST biliary cholangitis Celiac Celiac Celiac

Question 20

SCID Type T-B+NK+ T-B+NK- T-B-NK+ T-B-NK-

Answer 20

T-B+NK+: IL-7R alpha chain T-B+NK-: IL2R gama, JAK3 T-B-NK+: RAG1/2 T-B-NK-: Adenosine deaminase

Question 21

Which type of T cell defend against fungus

Answer 21

Th17, secret IL17, is crucial in the control of C albicans