Qmax- Immu Flashcards
What in eosinophils that fight against protozoan infection
Major basic protein
Meningitis of 0-6 month old kid
Group B Strep E. coli Listeria
Wiskott-Aldrich syndrome
Abnormal cytoskeleton reorganization impairing cell signaling Present as: thrombocytopenia, recurrent infections with encapsulated organisms, eczema, and increased risk of autoimmune diseases
Hyper IgE syndrome
STAT3 gene (AD) or DOCK8 gene (AR) Deficiency of Th17 Recurrent pneumonia caused by Staphylococcus aureus and Aspergillus fumigatus, deep organ abscesses, mucocutaneous candidiasis, hyperflexible joints, and recurrent fractures
Celiac disease is associated with
IgA deficiency (Giardia), iron-deficiency anemia, autoimmune thyroid disease, type 1 diabetes, and dermatitis herpetiformis
Type II hypersensitivity
Grave’s disease, Goodpasture
Type III hypersensitivity
Poststreptococcal glomerulonephritis, Polyarteritis nodosa, Serum sickness
Inactivated vaccines
RIP Always: Rabies, Influenza (injection), Polio (Salk), hepatitis A
t(11;14) t(11;18) t(14;18) t(15;17)
t(11;14): Mantle cell lymphoma (cyclin D1 activation) t(11;18): Marginal zone lymphoma t(14;18): Follicular lymphoma (BCL-2 activation) t(15;17): APL (M3 of AML, Aeur rod!)
HLA-B8 HLA-BW22 HLA-DR3 HLA-DR4
HLA-B8: Graves disease HLA-BW22: Kawasaki disease HLA-DR3: active autoimmune hepatitis, Sjögren, DM1 HLA-DR4: RA, DM1
Ataxia Telangiectasia
a mutated ATM gene that results in defective DNA repair mechanisms (AR) -Low Ig A -Telangiectasias -Cerebellar degeneration: a staggering gait (ataxia), strabismus, oculomotor apraxia, nystagmus, difficulty with fine motor movements, dysarthria, chorea, athetosis, dystonia, and tremor.
Adenosine deaminase deficiency: heritage?
AR
Drug-induced immune hemolytic anemia
Penicillin acts as a hapten to cause RBC hemolysis. A hapten is a small molecule that cannot elicit an immune response on its own. It must form a complex with a large carrier, such as a protein, to be immunogenic.
Poison ivy
Allergic contact dermatitis
What type of immune response to parasites
Antibody-mediated destruction of parasites by eosinophils is referred to as antibody-dependent cell-mediated cytotoxicity
What the cause of sarcoidosis granuloma
A cell-mediated immune response to an (unidentified) antigen
Chédiak-Higashi syndrome
Wiskott-Aldrich + albinism
IL-12 receptor deficiency
Decrease Th1 response, AR, Disseminated mycobacterial and fungal infections
anti-CCP anti-Jo1 anti-Ro/SSA anti-La/SSB anti-Scl70 Anticentromere Antimitochondrial anti-endomysial anti-tissue transglutaminase deamidated gliadin peptide
RA Polymyositis, dermatomyositis Sjögren Sjögren Scleroderma CREST biliary cholangitis Celiac Celiac Celiac
SCID Type T-B+NK+ T-B+NK- T-B-NK+ T-B-NK-
T-B+NK+: IL-7R alpha chain T-B+NK-: IL2R gama, JAK3 T-B-NK+: RAG1/2 T-B-NK-: Adenosine deaminase
Which type of T cell defend against fungus
Th17, secret IL17, is crucial in the control of C albicans
