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Step 1 > QB - PHARM1 > Flashcards

QB - PHARM1 Flashcards

1
Q

Failure of alveolar air to equilibrate w/ venous blood gases; possible cause?

A

Poor perfusion – no exchange btwn alveoli & vessels (normal equilibration is pO2 ~100mmHg and pCO2 ~40mmHg)

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2
Q

Significant side effects of antihyperlipidemic medications

A

Statins - hepatoxicity, muscle toxicity

Fibrates - muscle (esp combined w/ statins); gallstones

Bile acid sequestrants - DECREASE absorption of digoxin, warfarin, fat-soluble vitamins; nausea, bloating, cramping

Niacin - hepatotoxicity; flushing, warmth, pruritus

Ezetimibe - hepatotoxicity (esp. with statins)

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3
Q

Blood supply of spleen

A

Splenic artery from celiac trunk (foregut) BUT spleen is MESODERM-derived

foregut: esophagus –> 2nd part of duodenum, liver, gallbladder, and small portion of pancreas

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4
Q

Nesiritide

A

BNP (brain natriuretic peptide)

dilates arteriole & veins - promotes diuresis

usually released in pts. w/ systolic dysfunction in CHF (increased heart volume in heart that can’t pump out a lot of blood –> increased stretching triggers ANP from atria or BNP from brain to be released to decrease volume)

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5
Q

Bradykinin relationship to adrenergic and renin-AT-aldosterone system

A

Bradykinin produced by kidneys when adrenergics and renin-AT-aldosterone system activated

Constricts veins, dilates arterioles –> increase renal perfusion

ANGIOEDEMA

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Step 1 (6 decks)

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