Q bank III Flashcards by ROSCIAE SAVIOR

Which of the following can you absorb if you have Cystinuria?

You can Absorb Leucine

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Homocystinuria caused by

Cystathionine Beta Synthase

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Which apolipoprotein does LDL receptor interact with?

Apo E and ApoB

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What is responsible for Chylomicron remnant not being endocytosed?

FH type 3

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What can lead to accumulation of Uric Acid?

A decrease in Km of PRPP synthetase

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Decreased insulin/glucagon ratio in diabetics leads to what?

Increase in HSL release/ Decrease in glycolysis

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Increase in Uric Acid because a defect in?

HGPRT (Hypoxanthine-Guanine phosphoribosyl transferase)

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What enzyme is defect in Lesch-Nyhan?

HGPRT (Hypoxanthine-Guanine phosphoribosyl transferase)

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Deficiency in Tryptophan will lead to?

Problems in Serotonin metabolism

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Hartnup disease, one cannot absorb?

Large aromatic Amino acids (Such as tryptophan)

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Pheochromacytomas you can administer what?

MAO inhibitors

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Hemolytic anemia leads to?

Prehepatic Jaundice

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Hepatic anemia has the following except?

Direct bilirubin in Urine

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If a patient is hyperammonemic what is the worst possible treatment?

Diet high in good Proteins

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Damage of Pyruvate DHG damages what tissue the most?

Brain

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A man is at a clinic, he has problems, turns out his brother had lung disease, which of the following deficiencies?

Alpha 1- antitrypsin

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Most common Congenital Adrenal Hyperplasia?

Alpha-21 Hydroxylase deficiency

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A diet of low carbohydrate is most beneficial if

if the level of VLDL is high

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Epinephrine degraded to?

vanillylmandelic acid

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Gout is cause by deficiency of which enzyme?

Xanthine oxidase

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Lactic acidosis cause by?

Pyruvate dehydrogenase deficiency

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PFK activator?

AMP, F2,6BP

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after high carbohydrate meal will cause these two enzyme increase or decrease?

lipoprotein lipase will increase and hormone stimulate lipase will decrease

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Type 2 hyperproteinemia

deficiency of LDL receptor can cause cholesterol and cholesterol ester high in blood.

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Cerebroside accumulation

Gaucher’s disease

Urea synthesis in liver and nitrogen compound come from?

Asp and Ammonia

Which organ can synthesis ketone bodies but can’t use it as energy source?

liver

L-dopa convert to dopamine require?

Methyl group of methylation require in many pathway synthesis r come from?

SAM

Serotonin and niacin synthesis from?

Trptophan

Lead can inhibit which enzyme?

ALA dehydratase and ferrochelatase

Breakdown propionyl-CoA to succinyl-CoA require?

Biotin and B12

Malonyl-CoA is inhibitor of

carnitine palmitoyltransferase (CPT)Ι then beta-oxidation will decrease and fatty acid synthesis increase.

High level of Acetyl-CoA can make fatty acid synthesis increase and

ketone bodies synthesis increase but fatty acid degradation decrease.

Why is DNA degenerative ?

4 nucleotides code for more than 20 aa

Methotrexate inhibits conversion of?

dump to dtmp

Methotrexate inhibits nucleotide synthesis via inhibiting which enzyme?

Folic acid to tetrahydrofolic acid

Aspirin is inhibitor of?

Cyclooxygenase

Which 2nd messenger used in gluconeogenesis?

Epinephrene

What is activator of fatty acyl carboxylase?

Insulin

Hormone-sensitive lipase is activated by elevated level of ?

cAMP

A person with a familial hyperlipidemia cause by a deficiency of LDL receptors was treated with an HMG CoA reductase inhibitor. This drug causes

This drug causes blood cholesterol levels to decrease

A patient with high blood cholesterol levels was treated with lovastatin .This drug lowers blood cholesterol levels because it inhibits:

HMG CoA reductase in liver and peripheral tissues

What enzyme deficiency cause SIDC (sudden infant death syndrome)

acyl CoA dehydrogenase

What amino acid are nonessential?

alanine ,tyrosine ,asparagines ,aspartate ,cysteine ,glutamate ,glutamine ,glycine ,glycine ,seine

Source of the individual atoms in the pyrimidine ring

amide nitrogen(R group) of glutamine ;CO2 ;Aspartic acid

Source of the individual atoms in the purine ring.

CO2 ;Glycine ;Aspartate ;Glutamine ;N10 formyl tetrahydrofolate

Lysosomal storage Diseases

Pompe’s disease ;Tay-Sachs ; Gaucher disease ;Fabry disease

Which one of the following occurs in the conversion of fatty acids to ketone bodies?

Acetoacetate and acetyl CoA are produced y cleavage of HMG CoA

Which of the following is a true statement regarding cytosolic carbamoyl-phosphate synthetase II in humans?

: it is one of the 3 activities residing in a single polypeptide called CAD complex

5-Phosphoribosyl 1 pyrophosphate (PRPP) is an intermediate inall the following pathways EXCEPT:

: the pentose phosphate pathway

. Thymidylate synthase, an enzyme whose activity is high in rapidly dividing tumor cells, performs all the following function EXCEPT:

providing pyrimidine nucleotides for mRNA synthesis

The mechanism of action of glucagon involves all of the following steps EXCEPT

activation protein kinase

the enzyme in the heme biosynthetic pathway that is most sensitive to lead is

Aminolevulinic acid (ALA) dehydratase

The first step in heme catabolism

heme oxygenase

The rate limiting step in urea cycle is

carbamoyl phosphate synthetase I

Which one of the following enzymes is rate limiting for de novo purine nucleotide synthesis and is thus a target for drugs used in treatment in gout?

phosphoribosylpyrophosphate-glutamine amidotransferase (PRPP amidotransferase

The elevation of blood ketone bodies results from deficiency of the enzyme

e-succinyl CoA-acetoacetate CoA-transferase

The administration of L-dopa which is given in the treatment of Parkinson’s disease bypass the rate limiting enzyme of catecholamine biosynthesis. What is the name of the enzyme?

tyrosine hydroxylase

Which of the following is true concerning transketolase

It utilizes TPP as cofactor in catalyzing the transfer of two carbon fragment from one sugar phosphate to another

Dinitrophenol uncouples oxidation and phosphorylation in which one of the following ways?

By dissipating the proton gradient between the mito matrix and the intermembrane space

All of the following are true statements regarding glutamine PRPP amidotransferase EXCEPT:

it is activated by IMP

True statement about enzyme inhibits include all the following EXCEPT

captopril is uncompetitive inhibitor of an angiotensin converting enzyme

The congenital deficiency of a1-antitrypsin is associated with susceptibility of

emphysema

Chronic or long term regulation of enzymatic activity as opposed to acute changes in enzymatic activity ,is best affected by which of the following regulatory controls?

synthesis or degradation of enzyme

The committed step in cholesterol synthesis from acetyl Coenzyme A is

formation of mevalonic acid from HMG CoA