Pyschiatry Flashcards
What are the risk factors for depression?
- Female sex
- Past Hx of depression
- FHx of depression/mental illness
- Chronic/severe illness
- Other mental health Dx
- Ethnicity (afro-carribean, asian, refugee)
- Significant life stressors
What investigations would you do to exclude physical causes when screening for depression?
- Blood tests:
- FBC, ferritin, B12 (anaemia)
- Blood glucose (DM)
- U&Es (electolyte imbalanace)
- Calcium levels (Vit D deficiency)
- TFTs (hypothyroidism)
- LFTs (liver pathology)
- CRP (infection)
- Other tests:
- magnesium levels
- HIV/syphillis serology
- drug screening (urine dip)
- Imaging:
- MRI/CT scan (if intracranial lesion suspected e.g. new onset headache or personality changes)
What screening tools are used for depression?
Patient Health Questionnaire-9 (PHQ-9). /27
- minimal (1 - 4)
- mild (5 - 9)
- moderate (10 - 14)
- moderately severe (15-19)
- severe (20-27)
Hospital Anxiety and Depression scale. [Each section: 7Q, /21]
- normal (1 - 7)
- mild (8 - 10)
- moderate (11 - 14)
- severe (15 - 21)
What screening tool is used for suspected Postnatal depression?
Edinburgh Postnatal Depression questionnaire
What is the ICD-10 criteria for depression?
The depressive episode must last >2 wks and represent a change from normal.
This must not be secondary to other causes such as drugs, alcohol misuse, medication etc.
- CORE SYMPTOMS*
1. Low mood
2. Anhedonia
3. Reduced energy/fatigue
OTHER SYMPTOMS:
- Reduced concentration and attention
- Reduced self-esteem/self-confidence
- Ideas of Guilt and worthlessness
- Bleak and pessimistic views of the future
- Ideas or acts of self harm or suicide
- Sleep disturbance
- Diminished appetite
What are the psychotic symptoms associated with depression?
*Delusions:
are usually mood congruent and therefore usually nihilistic; poverty, over bearing guilt for misdeeds, responsible for world events, deserving of punishment.
*Hallucinations:
can occur in a range of modalities however 2nd person auditory hallucinations are most common;
- Auditory: derogatory voices, cries for help or screaming
- Olfactory: usually bad smells such as rotting flesh and faeces.
- Visual: demons, the devil, torturers, dead bodies etc.
*Catatonic symptoms:
marked psychomotor retardation aka depressive stupor.
How do we measure the severity of depression?
- Mild:
2 core + 2 other symptoms - Moderarte:
2 core + 3+ other symptoms - Severe:
3 core symptoms + 4+ other symptoms - Severe depression with psychosis:
Severe depression (as above + psychotic symptoms (delusions +/- hallucinations)
What is the role of 5HT and NA in mental and physical processes?
- Anxiety
- Pain perception
- Vasoconstiction
- Urethral sphincter contraction
- Bladder wall relaxation
- GI motility
- Pilomotor contraction
DDx for depression
- Medications:
- Anti-hypertensives: BB, CCB, methyldopa
- steroids
- histamine H2 blockers
- sedatives
- muscle relaxants
- retinoids
- chemotherapy agents
- sex hormones e.g. oestrogen etc.
- psychiatric medications
- Substance misuse:
alcohol, benzodiazepines, opiates, marijuana, cocain, amphetamines etc.
- Psychiatric illness:
bipolar, dysthmia, anxiety disorder, schizoaffective disorder, schizophrenia (negative symptoms), personality disorder
- Neurological:
dementia, Parkinson’s disease, tumours, stroke etc.
- Endocrine:
hyper/hypothyroidism, Addison’s disease, Cushing’s disease, menopause, hyperparathyroidism
- Metabolic:
hypoglycaemia, hypercalcaemia, porphyria
- Others:
anaemia, infections (syphillis, lyme disease, HIV encephalopathy), sleep apnoea
What is the treatment for mild-to-moderate depression?
- Bio:
- watchful waiting, assess in 2 weeks
- Psycho:
- Guided self-help based on CBT principles (books, internet resources)
- Computerised CBT
- Brief psychological interventions (6-8 sessions) including problem-solving, brief CBT and counselling.
- Social:
- reduce stressors
- establish support network
- enhance protective factors
What is the treatment for moderate-severe depression?
Bio:
- antidepressant
- ECT
- v. severe symptoms, treatment resistant or life-threatening
Psycho:
- high-intensity psychological treatment (CBT or interpersonal therapy)
Social:
- establish support network
- enhanced protective factors
What factors necessitate admission in depression?
- self-neglect
- risk of suicide/self-harm
- risk to others
- poor social support
- psychotic symptoms
- lack of insight
- treatment resistant depression
What are the pharmacological treatments for depression?
- Selective Serotonin Re-uptake Inhibitors
e,g, Sertraline, Citalopram/Esciralopram, Fluoxetine, Paroxetine
NB: As effective as TCAs and less likely to cause side effects and safer in overdose.
- Tricyclic Antidepressants
e. g. Amitriptyline, Imipramine - Serotonin-Noradrenaline re-uptake inhibitors
e. g. Venifaxine/Duloxetine - Monoamine-oxidase inhibitors
e. g. Moclobemide - Noradrenergic and specific adrenergic antidepressant (NaSSA)
e. g. Mirtazapine - Agomelatine: melatonin receptor agonist
- Combination/augmentation therapies
- Atypical antipyschotics.
What are the SE of SSRIs?
- Increased suicidality <25
- Serotonin syndrome
- Discontinuation
What are the psychological treatment options for depression?
- CBT**
- Interpersonal therapy
- Psychodynamic psychotherapy
- Pyschoeducation
What are the social interventions in depression?
Very dependent on the specific social needs
- counselling (supportive/relationship/grief)
- improving social circumstances e.g. vocational training, supported accommodation, benefits.
- address safe-guarding concerns
What are the clinical features of atypical depression?
- Mood: mood is depressed but remains active i.e. can still enjoy activities.
- Extreme fatigue
- Reversed diurnal variation in mood
- Hypersomnia: excessive sleeping which can be defined as >10hours/day, at least 3 days a week for at least 3 months.
- Hyperphagia: excessive eating with weight gain (>3Kgs in 3 months).
- Interpersonal rejection sensitivity
- Leaden paralysis: feelings of heaviness in the limbs (1hr/day, 3 days/week for at least 3months).
What are the clinical features of dsythmia?
- Depressed mood (>2 years)
- Reduced energy and fatigue
- Appetite may be increased/reduced
- Insomnia/hypersomnia
- Low self esteem
- Poor concentration
- Difficulties making decisions
- Thoughts of hopelessness
What is dysthmia?
This is the presence of chronic low grade depressive symptoms.
These are usually long standing e.g. years but there is a time when the person did feel ‘well’. It is possible to experience a depressive episode i.e. double depression in which case need to be aware that the baseline is dysthymic rather than euthymic.
What are the risk factors for post-natal depression?
- FH
- single mum
- older age mum
- unwanted pregnancy
- poor social support
- poor relationship with own mother
What is Seasonal affective disorder (SAD)?
This is low mood which occurs with a change in season i.e. depression in winter and remission in spring.
The underlying pathology is believed to involve melatonin synthesis; sunlight hits the pineal gland which decreases melatonin synthesis (↑5HT synthesis).
What is the management of Seasonal affective disorder?
- Light therapy (go outside, specialised SAD lights)
2. Pharmacological: antidepressants (SSRIs), propranolol
You are an F1 doctor working on a psychiatric ward.
Mr Steven Jones is a 31yr old man who is admitted under S2 MHA.
The handover you are given is that he is suffering from mania.
When you try to speak to him, Mr Jones is pacing around the ward, he is continually speaking and can’t remain on a topic.
When you ask ‘how are you?’ he replies ‘fine…. Like a biro pen….they have ink…….I really want a tattoo….I wonder what its like in prison…are you the police?’
Identify the thought disorder?
Flight of ideas.
What is the ICD-10 criteria for Bipolar affective disorder?
“at least two episodes one of which must be hypomanic/manic or mixed, with recovery usually complete between the episodes”.
The criteria for the depressive episode being the same as for unipolar depression, and the criteria for the hypomanic/manic episodes being the same as unipolar hypomania/mania.
*NB Mixed affective episodes is when there is the occurrence of both hypomanic/manic and depressive symptoms in a single episode present everyday for at least 2 weeks.