pyruvate dehydrogenase complex

Question 1

4 fates of pyruvate; and which one is in aerobic resipiration

Answer 1

acetyl-CoA, oxaloacetate (OAA), lactate, alanine

pyruvate -> acetyl-CoA in aerobic respiration

Question 2

vitB1-3, 5, lipoic acid are ___ needed in PDH

Answer 2

required co factors

Question 3

factors that lead to activation of PDH phosphatase

Answer 3

increased glucose, insulin

(post prandial when levels are high/FED STATE)

Question 4

factors that deactivate PDH kinase

Answer 4

decreased glucose (fasting), acetyl-CoA

Question 5

PDH is similar to which cycle: same cofactors, substrate structure, add CoA

Answer 5

alpha ketoglutarate dehydrogenase (TCA CYCLE)

Question 6

PDH complex is a series of (2/3/4) enzymes that work together to break pyruvate down to acetyl-CoA & NADH

Answer 6

3 ENZYME Complex

Question 7

PDH deficiency results in a build up of pyruvate, and an increase in shunting to which 2 substrates

Answer 7

lactate and alanine