Purpura, etc

Question 1

what is purpura

Answer 1

non-blanch, pink/purple macules/patches or papules caused by extravasated RBC in skin or muc memb. “blood in skin”

Question 2

purpura causes

Answer 2

1. coag/clotting prob
2. leaky /abnormal vessels
3. other (trauma eg)

Question 3

macular/non palp purpura

Answer 3

non inflamm

Question 4

palpable purpura

Answer 4

vasculitis

Question 5

petechiae

Answer 5

small <3 mm red or purple dots. Usually on dependent areas of body. no pain usually

Question 6

who will have petechiae: hemaphilia or chemo?

Answer 6

pt w chemo because thrombocytopenic

Question 7

think petechiae, think ___

Answer 7

PLATELETS (low or dysfunctional)

Question 8

are there non-platelt related petechiae?

Answer 8

yes! things that increase cap fragility or allow leaking

Question 9

example of petechiae

Answer 9

scurvy

Question 10

ecchymosis

Answer 10

non palp purpura!
larger >5 mm
any part of body
could be painful or not, tender

Question 11

eccymosis is due to…

Answer 11

abnormal coag! not platelet defects

hyper OR hypo coag

Question 12

causes of purpura

Answer 12

thrombocytopenia _ inf/inflamm/truama
abnormal paltelet fn + inf/inflamm/truama
infection
anticoag + truama (DIC, renal/hep dysfn, anticoag med, vitK defy)
poor dermal support + trauma (actinic damage, amyloid, steroid atrophy, Ehlers-Danlos, trauma, scurvy)

Question 13

linear purpura

Answer 13

thrombocytopenia + trauma

Question 14

henoch-schonlein purpura

Answer 14

assoc w kidney dis bc vaculitis
watch for pregnant women too
PALPAPLE

Question 15

classification of vasculitides

Answer 15

size of vessel!

Question 16

size of vessel determines what in vasculitides

Answer 16

clinical findings

classification

Question 17

small vessel vasculitis

Answer 17

Henoch Schonlein purpura
infections
drug rxns
A/I
malig-assoc vasc
idiopathic/ H/S rxn

Question 18

polyarteritis nodosa

Answer 18

big vessel vasculitis

Question 19

medium vessel vasculatis

Answer 19

not as much palpable purpura.

Question 20

most scary form of purpura?

Answer 20

retiform purpura!!

Question 21

what is retiform purpura

Answer 21

distinctive ecchymosis w “netlike” pattern
due to vasc ischemia bc underlying thrombotic disorder
widespread = purpura fulminans
infection, congenital coag def (protein C defy)
acute thrombotic event
if fever, infection esp meningococcemia! eek.

Question 22

purpura fulminans

Answer 22

widespread retiform purpura