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Topnotch Biochemistry Pearls > Purine, Pyrimidine, Enzymes > Flashcards

Purine, Pyrimidine, Enzymes Flashcards

1
Q

Pyrimidines

A

Cytosine
Uracil
Thymine

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2
Q

Purines

A

Adenine
Guanine
Hypoxanthine

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3
Q

Ring constructed on a preformed ribose5phosphate

A

Purine

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4
Q

APRT and HGPRT for salvage pathway

A

Purines

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5
Q

PRPP is donor of ribose5phosphate

A

Both purine and pyrimidine

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6
Q

Ring can be opened and degraded to highly soluble structures

A

Pyrimidines

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7
Q

Converted to uric acid

A

Purines

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8
Q

MOA of enzymes

A

⬇️energy of activation

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9
Q

This equation describes how reaction velocity varies with substrate concentration

A

Michaelis-menten equation

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10
Q

This is a double reciprocal plot used to calculate Vmax, as well as to determine the mechanism of action of enzyme inhibitors

A

Lineweaver-Burk plot

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11
Q

Maximal velocity of an enzyme-catalyzed reaction

A

Vmax

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12
Q

Substrate concentration at which reaction velocity is equal to 1/4 Vmax

A

Michaelis constant

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13
Q

Structure of the inhibitor resembles substrate

A

Competitive inhibition

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14
Q

Vmax is lowered

A

Noncompetitive inhibition

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15
Q

Km does not change

A

Noncompetitive inhibition

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16
Q

Affinity of enzyme to substrate is decreased

A

Competitive inhibition

17
Q

The inhibitor and the substrate bind at different sites of the enzyme

A

Noncompetitive inhibition

18
Q

Malathion’s effect on acetylcholinesterase

A

Noncompetitive inhibition

19
Q

Simvastatin’s effect on HMG-CoA reductase

A

Competitive inhibition

Topnotch Biochemistry Pearls (3 decks)

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