Purine metabolism

Question 1

what cause gout

Answer 1

hyperuricemia - high uric acid
-casing ruin acid crystals

Question 2

What is uric acids solubility in plasma

Answer 2

-poor
-lower the pH = less soluble this easily forms into crystals
-big joint most affected

Question 3

uric acid comes from metabolism of which group of molecules

Answer 3

-purines
-adenine, guanine, hypoxanthine & xanthine

Question 4

list the sources of purine

Answer 4

-diet
-breakdown of nucleotides form tissue
-synthesis within body

Question 5

how do purines exit body

Answer 5

excretion via kidney (uric) and small breakdown in the gut

Question 6

why are women less likely to get gout

Answer 6

high oestogten is protective by upping excretion of uric acid but becomes less effective in menopausal women

Question 7

what converts purine to xanthine and xanthine to uric acid

Answer 7

both conversion by xanthine oxidase

Question 8

what are some complication of high uric acid

Answer 8

-kidney stones made of uric acid
this damages kidneys

Question 9

what enzyme promoted uric acid –> allantoin and why

Answer 9

Urate-oxidase enzyme
-allontoin is more soluble than uric acid and this is more easily excreted

Question 10

what enzyme converts purines back to body nucleotides

Answer 10

hypoxanthine-guanine phosphoribosyl transferase (HPRT)