Pure motor neurological disease

Question 1

Pure motor syndrome with fluctuating ptosis, diplopia, bulbar symptoms and limb weakness should make you think

Answer 1

NMJ

Question 2

Fluctuating and fatiguable weakness

Answer 2

Myesthenia

Question 3

tensilon test

Answer 3

edrophonium - boosts Ach improvement in response

Question 4

Repetitive nerve stimulation

Answer 4

stimulate the nerve at low frequency

decremental response with recurrent stimulation

Question 5

Managing myethenia graivs

1) symptomatic therapy

Answer 5

1- AntiAchesterase inhibitor
2- Plasma exchange
3- IVIG

Question 6

Managing myethenia graivs

1) Disease modifying therapy

Answer 6

• steroids - prednisone
• steroid-sparing agents
• thymectomy

Question 7

MG disease prognosis - today’s therapy

Answer 7

mortality < 5%

Question 8

A pure motor syndrome with proximal weakness should make you think

Answer 8

myopathy

- hyperthyroid - graves

Question 9

What investigations should be carried out for a myopathy?

Answer 9

• CK
• TSH
• ESR/CRP
• ANA

Question 10

Progressive!
PURE MOTOR
Mixed upper and lower motor neuron
bulbar and limb muscles

Answer 10

Diffuse motor neuron disorder