Pulmonology Flashcards
Asthma categories
Asthma Treatment Progression
Tx Athletic Asthma
Cromolyn or Nedocromil
(Stabilizers)
Eval of Acute Asthma Exacerbation
- PEFR
- ABG
- PE
Sputum with Carcot-Leyden Crystals, Curschmann Spirals, eosinophilia suggestive of?
Asthma
Tx Acute Asthma Exacerbation
- O2
- Albuterol/Ipratropium Nebs
- Corticosteroids
Tx Refractory Asthma Exacerbation
- Racemic Epi Nebs
- SubQ Epi
- IV Magnesium
(All together)
Histology: Adenocarcinoma
Mucin Glands
Dx: Adenocarcinoma of Lung
Percutaneous CT
b/c location is Peripheral
Tx: Adenocarcinoma of Lung
Surgery
Adenocarcinoma of Lung: Assoc. Exposure
Asbestosis
Histology: Squamous Cell Lung Ca
Intracellular bridges
Keratin pearls
Paraneoplastic Syndromes: Squamous Cell Lung Ca
Hypercalcemia
(PTH-rp)
Dx: Squamous Cell Lung Ca
Bronch/EBUS
(Centrally located)
Tx: Squamous Cell Lung Ca
Surgery
Histology: Small Cell Lung Ca
neuroendocrine granules on EM
Paraneoplastic Syndromes: Small Cell Lung Ca
Cushings (ACTH)
SIADH (ADH)
Lambert-Eaton Syndome
Dx: Small Cell Lung Ca
Bronchus, EBUS (Central)
Tx: Small Cell Lung Ca
Chemo + Radiation
VERY sensitive to chemo!
NO surgery
Possible locations of Carcinoid and Assoc. Sx
- Lung
- L-sided heart valve fibrosis
- Intestines
- R-sided heart valve fibrosis (lungs metabolize before reaching L heart)
- Both: flushing, wheezing, diarrhea
Dx: Carcinoid
U/A for 5-HIAA
Tx: Carcinoid
Surgery
Dx: Lung Cancer
- CXR
- CT scan
- Best = Bx
If Confirmed:
- PET-CT to stage
- PFTs (can they tolerate surgery?)
Who should be screened for lung cancer?
- Screening w/ annual low-dose chest CT
- Age 55-80
- Smoking (30 pack-years)
- Quit < 15 years ago
Characteristics of Lung Nodule making it Low Cancer Risk (4 S’s)
- Size < 8mm
- Surface: Smooth, Calcified
- Smoker
- Self: Age > 70
Characteristics of Lung Nodule making it High Cancer Risk (4 S’s)
- Size > 2cm
- Surface: Spiculated
- Smoking: No
- Self: Age < 45
Pleural Effusion Algorhythm
Light’s Criteria
Exudate if one of the following is true:
- LDH > 2/3 Upper Limit of Normal (~200)
- LDHfluid/LDHserum > 0.6
- Proteinfluid/Proteinserum > 0.5
Tx: Loculated Pleural Effusion
Thoracostomy (+/- tPA to increase flow)
If this fails: Thoracotomy
Dx: Suspected Pleural Effusion
Lateral Decubitus X-ray (Cheapest)
or
U/S
or
CT
Tx: Repeat Pleural Effusions
Pleurodesis
(Surgical/chemical elimination of pleural space)
Thoracentesis shows increased PMNs. Dx?
PNA
Thoracentesis shows increased leukocytes. Dx?
TB/Malignancy
Thoracentesis shows RBCs. Dx?
Hemothorax / Cancer
Thoracentesis shows Adenosine Deaminase. Dx?
TB
Thoracentesis shows triglycerides. Dx?
Chylothorax
Thoracentesis shows amylase. Dx?
Chylothorax
Tx: Chronic Thromboembolic Pulmonary HTN
Thrombectomy
Escalation of Therapy in COPD
- SABA (albuterol)
- LAMA (tiotropium)
- LABA
- ICS
- LDE4 inhibitors (roflumilast)
- Oral Steroids
Tx: Acute COPD Exacerbation
- O2
- Nebulizer tx
- Ipratropium > Albuterol
- Abx
- Doxycycline vs Azithro (prolongs QT so needs EKG first)
- Oral vs IV steroids
Dx: Possible COPD Exacerbation
- CXR - flattening of diaphragm
- ABG = CO2 retention (hypoxic hypercarbic respiratory acidosis)
- EKG
PCWP and LV Fxn in ARDS vs CHF
- ARDS = Non-cardiogenic Pulm Edema
- PCWP = Down
- LV Fxn = Up
- (Or Normal; Normal)
- CHF
- PCWP = Up
- LV Fxn = Down
Dx in ARDS
Clinical!
- CXR = Pulm edema; SICK!!!
- No fluid overload (ECHO shows normal heart, BNP normal)
Tx ARDS
- Intubation
- PEEP!
Can also increase respiratory rate to increase oxygenation
Causes of ARDS
- Gram Negative Septicemia
- TRALI
- Near-Drowning
Dx DPLD
- CXR
- High-res CT = ground glassopacities
- Bx
PFTs in DPLD
- Decreased FEV1
- Decreased FVC
- Normal FEV1/FVC
Tx DPLD
(General)
- ***STEROIDS***
- DMARDS
- Biologics
Conditions associated with Sarcoidosis
- Skin:
- Erythema Nodosum
- Lupus Pernio
- frost bite-like skin lesion
- Pathognomonic
- Eye:
- Uveitis = decreased vision/blindness
- Heart:
- Restrictive Lung Dz
- Heart Block
- Bells Palsy
Dx Sarcoidosis
- CXR = Bilateral Hilar Lymphadenopathy
- High-res CT
- PFTs = restrictive
- Bx = Non-caseating granuloma
Tx Sarcoidosis
Methotrexate and Cyclophosphamide
Extrapulmonary manifestations: Prednisone
Dx: Rule in Cardiac Sarcoid w/o Pulm manifestations
- Cardiac MRI
- Endomyocardial Bx
Restrictive Lung Dz and Sand Blasting
Silicosis
- Dx:
- CXR = Upper Lobe Nodules
- Note; rule out TB
- F/U:
- annual TB test
Restrictive Lung Dz and electronics
Berylliosis
Restrictive Lung Dz and coal
Coal Miner’s Lung
- Caplan’s Syndrome
- Arthralgia + Pulm Fibrosis
- Dx: r/o RA with RF or anti-CCP
Restrictive Lung Dz and Rock Quary Work
Silicosis
- Dx:
- CXR = Upper Lobe Nodules
- Note; rule out TB
- F/U:
- annual TB test
Restrictive Lung Dz and Aeronautics
Berylliosis
Restrictive Lung Dz and Farmer
Hypersensitivity Pneumonitis
- Dx: Gets better after day or two away from exposure
- Tx: remove exposure
Restrictive Lung Dz and Shipyard worker
Asbestosis
- Dx:
- CXR = Pleural plaques; mesothelioma
- Bx = Barbell Bodies
- Tx
- Smoking cessation
- F/U
- High risk adenocarcinoma and mesothelioma
Restrictive Lung Dz and Heavy Metal Exposure
Pneumoconiosis
O2 level below which the patient needs O2
55%