Pulmonary Path: COPD and Infection Flashcards
Centrilobar emphysema seen in a smoker; see dilation of alveolar airspaces due to dissolution of alv septa; distinguished from UIP in that alveolar septa are NOT thickened/fibrosed.
Bronchiolitis seen in a smoker
Bronchopneumonia seen in a smoker; see dense alveolar infiltrates
UIP (usual interstitial fibrosis); arrow pointing to area of fibrosis which is characteristically pink/eosinophilic.
Most commonly an idiopathic dz, though less commonly due to autoimmune dz, chronic hypersensitivity PNA, or chronic drug toxicity.
UIP; lung fibrosis with old and new (arrow) scar
Honey comb lung; send in end-stage pulmonary fibrosis, where airspaces are abnormally large and distorted, and separated by thick fibrous bands of CT. Most commonly seen in endstage UIP. Very little surface area for gas-exchange left, so pt very hypoxemic and survival only a few months if pt doesn’t get lung transplant.
Bronchiectasis in a CF pt; a severe necrotizing infection compounded by obstruction (mucostasis); see dense, dilated ducts with essentially absent acini. Normally see thick mucous clogging airways, which leads to bacterial colonization and secondary infection. Thus often see neutrophil infiltration in airways.
Acute bronchitis with intralumenal keratin-debris due to aspiration
Aspiration PNA with foreign body giant cells in lung parenchyma.
Bronchopneumonia with patchy neutrophils in lung parenchyma
Lobar PNA
Pneumonia with neutrophils in alveoli.
Organizing PNA
Organizing PNA with fibroblasts within alveolar spaces
CMV pneunomia with “owl eyes” (arrow); opportunistic infection of the immunocompromised (HIV, etc.)
Lung with granuloma; see giant cells within
TB: granuloma with caseous necrosis
Aspergilloma; a cavitary lesion with central necrosis and fungal hyphae
Aspergillosis; silver stain showing branching septated hyphae
Viral PNA with hyaline membrane
