Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Thoracic > Pulmonary Neoplasms > Flashcards

Pulmonary Neoplasms Flashcards

1
Q

What is the most common lung cancer?

A

Adenocarcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the second most common lung cancer?

A

SCC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Who does SCC of the lung usually occur in?

A

Male smokers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

If you are considering SCC of the lung in a young patients, female or non smoker, what should you consider first?

A

Mucoepidermoid carcinoma, poorly diff adenocarcinoma, metastasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Where do most SCC of the lung arise from?

A

Centrally in the main to segmental bronchi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the variants of SCC of the lung?

A

Papillary, clear cell, basaloid, and small cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the immunohistochemistry of SCC of the lung?

A

Positive for p40, p63, and high molecular weight cytokeratins
Negative for TTF-1 and napsin A
CK7 is positive in about 30%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How does adenocarcinoma of the lung present macroscopically?

A

Single, peripheral nodule, white in color with anthracotic pigmentation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

On cytology, what is a helpful clue that the lung is benign?

A

Presence of cilia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is adenocarcinoma in situ of the lung?

A

Single lesion, 3 cm or less, neoplastic cells grow exclusively along preexisting alveolar structures without stromal, vascular or pleural invasion
Papilla and micro papillae must be absent
Generally composed of nonmucinous cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Why are adenocarcinoma in situ and minimally invasive adenocarcinoma important?

A

Because if completely excised they have a 100% cure rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the immunohistochemistry of adenocarcinoma of the lung?

A

Diffuse CK7 positive
80% express TTF-1 and napsin A
P40 is always negative
P63 is occasionally positive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Is squamous cell carcinoma of the lung related to HPV?

A

Generally no

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How can you tell the difference between lung SCC and thymic SCC?

A

Thymic SCC tend to be more organoid and express CK5 and CD117 more frequently than lung

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What can be confused for adenosquamous carcinoma in the lung?

A

Peripheral SCC that entraps pneumocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are features that are considered invasion and must not be present in adenocarcinoma in situ?

A

Papillae or micro papillae

17
Q

What are the growth patterns for adenocarcinoma in the lung?

A

Lepidic, acinar, papillary, micro papillary, and solid

18
Q

How do the growth patterns in lung adenocarcinoma correlate to grade?

A

Lepidic is grade I
Acinar and papillary is grade II
Micro papillary and solid is grade III

19
Q

What are some histologic features in lung adenocarcinoma that are associated with a poor prognosis?

A

Signet ring cells and large collection of tumor cells in alveolar spaces isolated from the main mass

20
Q

Is adenosquamous of the lung main peripheral or central?

A

Peripheral

21
Q

What is required to call adenosquamous carcinoma of the lung?

A

Two components closely merging and each comprising at least 10%

22
Q

Does vascular or lymphatic invasion modify staging of carcinoids of the lung?

A

No

23
Q

What do peripheral carcinoids tend to show histologically?

A

Prominent spindle cell growth pattern with some whorl formation

The finding of an organoid pattern, stromal hyalinization, spindle-to-oval cell population, and finely dispersed nuclear chromatin support carcinoid and lack of necrosis

24
Q

How does IHC help for pulmonary paraganglioma vs carcinoid?

A

Paraganglioma is positive for neuroendocrine but negative for CKs

25
Q

What are the most specific and sensitive neuroendocrine markers?

A

Chromogranin A, synaptophysin, CD56/NCAM

26
Q

What does large neuroendocrine require histologically besides large cells?

A

Greater than 10 mitotic figures per 2 mm squares

Nucleoli are prominent and there is comedy-like necrosis

27
Q

How do more than 90% of small cell lung carcinoma present?

A

Centrally located, infiltrate the hilar structures, advanced/metastatic disease

28
Q

What are the types of sarcomatoid carcinoma in the lung?

A

Pleomorphic carcinoma, spindle and/or giant cell carcinoma, carcinosarcoma, pulmonary blastoma

29
Q

Which sarcomatoid carcinoma of the lung is associated with extensive angio invasion?

A

Spindle cell carcinoma

30
Q

What is a characteristic of giant cell carcinoma of the lung?

A

Has discohesive, pleomorphic, mono or multinucleated giant cells intermixed with inflammatory infiltrate of neutrophils
There can be inflammatory cells inside the tumor cell cytoplasm

31
Q

Where does giant cell carcinoma of the lung like to metastasize to?

A

The small intestine

Thoracic (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions