Nonneoplastic Flashcards
What is associated with the development of idiopathic pulmonary fibrosis?
Smoking, GERD, drugs, exposure to wood and metal dust
Variant in the promoter of MUCB gene
How does idiopathic pulmonary fibrosis present?
Middle to old age with gradual onset of exertion all dyspnea over months or years associated with bibasilar Velcro-type fine end-inspiratory crackles
40% have an associated viral infection
What is the major cause of idiopathic pulmonary fibrosis?
Alteration in the ventilation-perfusion relationship that stems from the ventilation of underperfused lung tissue as a result of capillary destruction and perfusion of under ventilated alveoli brought about by the profound structural lung alterations
What should be ruled out prior to diagnosing usual interstitial pneumonia?
Connective tissue diseases, chronic hypersensitivity pneumonitis, pneumoconiosis, chronic infection, chronic aspiration, and drug effect
What is the median survival for idiopathic pulmonary fibrosis?
2 to 3 years
What will RA have on lung biopsy besides UIP?
Peribronchiolar lymphoid nodules and more inflammation
What will scleroderma have on lung biopsy besides UIP?
May show lymphoid nodules or pulmonary artery medial mucinous changes or laminated fibrosis
What can help tell the difference between chronic hypersensitivity pneumonitis and interstitial pulmonary fibrosis?
Upper lobe for cHP
Lower lobe for IPF
What are some histologic characteristics of nonspecific interstitial pneumonia?
Low magnification demonstrates uniform fibrosis
Diffuse lymphocytic infiltration expands the interstitium
Hyperplasia of type II cells and alveolar macrophages
What is cryptogenic organizing pneumonia?
Organizing pneumonia with unknown etiology
Affects nonsmokers in their 6th decade
Less than 3 month complaint of cough and have been tried on at least one antibiotic
What are radiologic features of cryptogenic organizing pneumonia?
Patchy sub pleural, peri bronchial, or band like consolidations with air bronchograms
The consolidations migrate in subsequent studies
The reverse halo sign - ground glass opacities surrounded by consolidations
