Pulmonary Hypertension (Pulmonary)

Question 1

Calcium Channel Blockers (CCBs)

Answer 1

Example: Amlodipine (DHP)

MOA:
– Block L-type Ca-channels –> vasodilation

AEs: Hypotension, Headache

CIs: N/A

Question 2

Endothelin receptor antagonists

Answer 2

Example: Macitentan, ambrisentan

MOA: Block ET receptors –> vasodilation

AEs: Hypotension, Headache
– Hepatotoxicity

Contraindication:
– Pregnancy (BBW)

Question 3

Eicosanoids

Answer 3

Example: PGI2 analogs “prosts” and PGI2
agonists: Epoprostenol

MOA: Stimulate IP receptors on vascular SM
–> vasodilation

AEs: Hypotension, Headache
– GI adverse effects
– Jaw pain, pain in extremities

CIs: N/A

Question 4

NO and other sGC activators

Answer 4

Example: NO and Riociguat

MOA: Activates sGC in VSM –> increases cGMP
–> vasodilation

AEs: Hypotension, Headache

CIs: N/A

Question 5

PDE5 inhibitors

Answer 5

Example: Sildenafil

MOA: Inhibit PDE5 in vascular SM –> decreases degradation of cGMP –> vasodilation

AEs: Hypotension, Headache

CIs: Patients taking organic nitrates