Pulmonary HTN

Question 1

Epoprostenol

Answer 1

Class: Prostaglandin
Synthetic PGI2
Continuous infusion

MOA:

• Lowers peripheral pulmonary resistance
• Lowers coronary resistance

Use(s):
- Pulmonary HTN

Adverse Effect(s):

• Flushing
• Headache
• Jaw pain
• Diarrhea
• Arthralgias

Question 2

Bosentan

Answer 2

Nonselective Endothelin Receptor Blocker

MOA:

• Blocks initial transient depressor (ETa)
• Blocks prolonged pressor (ETb)

Use(s):
- Pulmonary HTN

Contraindication(s):
- Pregnancy category X

Question 3

Sildenafil

Answer 3

Class: Inhibitor of Phosphodiesterase 5

AKA: viagra

MOA:
- Inc. cGMP –> SM relaxation

Use(s):
- Pulmonary HTN

Adverse Effect(s):

• Headache
• Flushing
• Dyspepsia
• Cyanopsia

Contraindication(s):
- Nitrates