Pulmonary Circulation Flashcards
Endothelin-1/thromboxane-A2 may enhance HPV; NO and prostacyclin may moderate HPV; drugs targeting endothlin-1, NO, COX etc. may improve exercise capacity
Kylhammer and Radegran, 2017
Oxygen sensing in pulmonary arterial smooth muscle of pre-capillary vessels
Sommer et al, 2016
Tibetan people at altitude have lower HPV
Groves et al, 1993
Pulmonary capillary endothelial cells respond to hypoxia with membrane depolarisation
Wang et al, 2012
No evidence found for capillary constriction
Conhaim et al, 2008
Sensitivity to calcium enhanced via hypoxia-induced increase in Rho kinase activity
Weigand et al, 2011
High altitude exposure increases markers of ROS production, with less bioactive vasodilating NO species
Bailey et al, 2010
CO production upregulated by hypoxia
Llanos et al, 2012
Heterozygous HIF1α deficient mice have weaker acute and chronic hypoxia responses
Shimoda et al, 2001
Carotid body sensitivity to hypoxia decreased in HIF1α knockouts
Kline et al, 2001
HPV does not improve Va/Q matching in humans
Gale et al, 1985
Increased ROS in hopxia activates HPV
Schumacker et al, 2011
CFTR and sphingolipids mediate HPV
Tabeling et al, 2015
Mouse model of Leigh syndrome (complex I) shows impaired HPV
Schleifer et al, 2018
Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice
Murtaza et al, 2018
