Pulmonary Arterial Hypertension Flashcards
What agents are used to treat PAH?
dihydropyridines
sildenafil
prostacyclin analogs
endothelin antagonists
What are the 3 forms of PAH?
idiopathic
familial
associated
What is the most common form of PAH?
associated
What are the potential causes of associated PAH?
connective tissue disease congenital heart disease portal hypertension HIV schistosomiasis sickle cell disease anorexic drugs
What are the clinical presentations of PAH?
exertional dyspnea, fatigue
lower leg edema, bloating, anorexia
heart murmmers, valve disease
How do you confirm diagnosis of PAH?
right heart catheterization
What are the goals of PAH treatment?
alleviate symptoms/ improve QoL
prevent disease progression
improve survival
What are some nonpharmacological treatment options for PAH?
CPAP for sleep apnea
surgery
reduce Na intake
What are the general pharmacological treatments for PAH?
anticoagulants
diuretics
oxygen
digoxin
Which CCBs are indicated for PAH?
dihydropyridines
What class does sildenafil fall under?
phosphodiesterase inhibitors
Why are phosphodiesterase inhibitors used?
increase cGMP mediated vasodilation
improve exercise tolerance
What effects does prostacyclin have?
vasodilator
platelet inhibitor
antiproliferative
What is epoprostenol (Flolan)?
synthetic analog
What is treprostinil (Remodulin)?
stable analog
