Pulmonary

Question 1

PFT in asthma

Answer 1

FEV1 and FVC decreased, but FEV1 more than FVC so FEV1/FVC ratio is also decreased. FEV1 inc with > 12 % with beta2 agonist (albuterol) dec in FEV1>20 % with metacholine. Inc in diffusion capacity of lung for carbon monoxide (DLCO)

Question 2

Sarcodosis definition

Answer 2

Chronic granulomatous disease characterized by noncanseating granulomas. Often involved multiple organ systems, lungs are almost always involved. 75 % occurs before 40 yrs, Inc risk in african americans.

Question 3

Clinical

sarcoidosis

Answer 3

constitutional symptoms, lungs, skin, heart, musculoskeletal system, nervous system.

Question 4

DX

sarcoidosis

Answer 4

bilateral hilar adenopathy, skin anergy, elevated ACE, hypercalciuria,hypercalcemia, definitive diagnosis: transbronchial biposy.

Question 5

Tx

sarcoidosis

Answer 5

most resolve spontaneously in 2 yrs and do not need treatment. If treatment; systemic corticosteroids

Question 6

tx of TB

Answer 6

2 months with isoniazide (INH), rifampin, pyrazinamide, etambutolol/streptomycin, then 4 months with IHN and rifampin.