Pulmonary

Question 1

What does silicsis effect?

Answer 1

Macrophages

Affects upper lobes

Question 2

Pathogenesis of TB

Answer 2

Bacteria are phagocytosed by alveolar macrophages
TB has an ability to inhibit formation of an effective phaolysosome
In weeks after infection, APC cells display mycobacterial antigens to naive CD4 T lymphocytes
These differentiate into T helper cells that secrete INF gamma
INF gamma activates macrophages - these can kill the TB plus they grow into multimucleates giant cells
Release of proteases, NO, ROS kill the TB but damage the surrounding tissues

Question 3

What are some infectious complications of CF?

Answer 3

The thick mucous allows for growth of H influenza, staph aureus and then Gram neg rods such as pseudomonas.