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USMLE > Pathology > Flashcards

Pathology Flashcards

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USMLE® Step 1 flashcards
1
Q

What are signs of reversible cell injury

A

ATP pumps stop working, Ca and Na/K - cell oedema.
decreased protei synthesis
plasma membrane cahnges - blebs
nuclear changes - chromatin clumping

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2
Q

What are the signs of irreversible cell injury

A

Breakdown of cell membrane
Mitochondria dysfunction
Rupture of lysosymes - autolysis
pyknosis, karyorrhexis, karyolysis.

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3
Q

What is in charge of the intrinsic apoptosis?

A

BAX and BAK - proapoptotic, bcl-2 and bcl-xL - antiapoptotic.

active caspases.

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4
Q

What is seen in the histology of coagulative necrosis?

A

The cellular architecture is preserved but the nucleus is dissolved. stains pink/red colour

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USMLE (14 decks)

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